Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-04-13
1995-05-16
Johnston, Jill A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530322, 424450, 4241301, 4241941, A61K 3702, C07K 900
Patent
active
054160707
ABSTRACT:
The present invention provides novel lipophilic disaccharide-dipeptide compounds. The compounds of the invention are preferably encapsulated into multilamellar liposomes, which can be formed from phosphatidyl choline and phosphatidyl glycerol. The compounds are effective in activating human monocytes with subsequent destruction of tumor cells. These compounds have acceptable toxicity in anticipated human dosages.
REFERENCES:
patent: 3976544 (1976-08-01), Adam et al.
patent: 4042678 (1977-08-01), Ciorbaru et al.
patent: 4094971 (1978-06-01), Chedid et al.
patent: 4101536 (1978-07-01), Yamumura et al.
patent: 4153684 (1979-05-01), Audibert et al.
patent: 4158052 (1979-06-01), Audibert et al.
patent: 4172125 (1979-10-01), Audibert et al.
patent: 4185089 (1980-01-01), Derrien et al.
patent: 4186194 (1980-01-01), Adam et al.
patent: 4235771 (1980-11-01), Adam et al.
patent: 4256735 (1981-03-01), Durette et al.
patent: 4271151 (1981-06-01), Hotta et al.
patent: 4272524 (1981-06-01), Chedid et al.
patent: 4317771 (1982-03-01), Shiba et al.
patent: 4323559 (1982-04-01), Audibert et al.
patent: 4357322 (1982-11-01), Rooks, III et al.
patent: 4357323 (1982-11-01), Soma et al.
patent: 4370265 (1983-01-01), Adam et al.
patent: 4382080 (1983-05-01), Shiba et al.
patent: 4391800 (1983-07-01), Durette et al.
patent: 4395399 (1983-07-01), Ovchinnikov et al.
patent: 4396607 (1983-08-01), Lefrancier et al.
patent: 4397844 (1983-08-01), Baschang et al.
patent: 4401659 (1983-08-01), Lefrancier et al.
patent: 4406890 (1983-09-01), Tarcsay et al.
patent: 4414204 (1983-11-01), Tarcsay et al.
patent: 4427659 (1984-01-01), Lefrancier et al.
patent: 4435386 (1984-03-01), Ribi et al.
patent: 4436727 (1984-03-01), Ribi et al.
patent: 4436728 (1984-03-01), Ribi et al.
patent: 4446128 (1984-05-01), Baschang et al.
patent: 4461761 (1984-07-01), Lefrancier et al.
patent: 4505899 (1985-03-01), Ribi et al.
patent: 4505900 (1985-03-01), Ribi et al.
patent: 4515891 (1985-05-01), Yokogawa et al.
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4545932 (1985-10-01), Takase et al.
patent: 4770874 (1988-09-01), Allison et al.
patent: 4950645 (1992-08-01), Vosika et al.
T. Andronova, et al., Chem. of Pept. and Prot., 1, 343 (1982).
D. G. Brown et al., Immunotoxicology, A. Belin, et al., Ed; Martin Hijhof, Pub.; 1987, pp. 219-233 Eur. J. Biochem., 143, 359 (1984).
M. Guinand, et al., Eur. J. Biochem., 143, 359 (1984).
W. R. Hargreaves, et al., Biochem., 17, 3759 (1978).
V. T. Ivanov, et al., "Synthesis, Structure and Biological Properties of Glycopeptides Containing the N-Acetyl-Glucosaminyl-O-(1-4)-N-Acetylmuramyl Disaccharide Unit", Proceedings of the Sixteen European Peptide Symposium, Brunfeldt K. ed., Striptor Copenhagen, 1991, pp. 494-500.
N. C. Phillips, et al., Cancer Res., 45, 128 (1985).
S. Sone, et al., Cancer Immunol. Immunother., 12, 203 (1982).
E. Ribi, et al., Ann. N.Y. Acad. Science, U.S.A., 277, 228 (1976).
G. Sava, et al., Cancer Immunol. Immunother., 18, 49 (1984).
G. Sava, et al., Cancer Immunol. Immunother., 15, 84 (1983).
Biological Abstracts, vol. 89, 1990 (Philadelphia, Pa., US) J. G. Vosika et al.: "Immunologic and Toxicologic Study of Disaccharide Tripeptide Glycerol Dipalmitoyl: A New Lipophilic Immunomodulator" (see p. 779, abstract No. 118879 & Mol Boiter 2(1): 50-56 1990.
Bennek John A.
Cornelius Dennis A.
Gilbert Carl W.
Swenson Karl E.
Vosika Gerald J.
ImmunoTherapeutics, Inc.
Johnston Jill A.
Touzeau P. Lynn
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