Composition for long acting nicardipine preparation and process

Details Composition for long acting nicardipine preparation and process Composition for long acting nicardipine preparation and process

1987-02-11

1988-07-19

Lusignan, Michael R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424457, 424501, 424502, A61K 914, A61K 916, A61K 920, A61K 3174

Patent

active

047584378

ABSTRACT:
A spherical pellet like composition of nicardipine composed of small granular nuclei such as sugar particles coated with amorphous nicardipine or a salt thereof, a pH-dependent additive and a surface active agent. The spherical pellet like composition of nicardipine may have a further coating of a medicament permeating material as an outermost coating. The spherical pellet like composition may be mixed with the spherical pellet like composition coated with the medicament permeating material.

REFERENCES:
patent: 3954959 (1976-05-01), Pederson
patent: 4193985 (1980-03-01), Bechgaard et al.
patent: 4223006 (1980-09-01), Taskis
patent: 4261971 (1981-04-01), Appelgren et al.
patent: 4343789 (1982-08-01), Kawata et al.
patent: 4353888 (1982-10-01), Sefton

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