Composition for locally treating the epidermis, especially the s

Details Composition for locally treating the epidermis, especially the s Composition for locally treating the epidermis, especially the s

1989-01-24

1991-02-26

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424 70, 424583, 514648, 514880, 514881, A61K 706

Patent

active

049960571

DESCRIPTION:

BRIEF SUMMARY
The invention relates to compositions for locally treating the epidermis.
More specifically, it concerns a composition intended for the local treatment of the epidermis, especially of the scalp, containing at least one principle active in the treatment considered and, as chemical mediator inducing the response of the receptors of said principle, at least one product resulting from the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde.
The products of this type have as general formula (C.sub.11 H.sub.15 NO).sub.n, n most frequently representing an integer from 2 to 4.
It would appear that these products result from the chaining of units of the following formula: ##STR1##
A product apparently consisting of a mixture of di-, tri- and tetramers of this unit is marketed by the SIGMA Company, P.B. 14508, Saint Louis, MO 63178, U.S.A. under the trade name "Compound 48/80".
This product also known under the name of "aromatic polyamine", is to be found under the form of hydrochloride of the general formula (C.sub.11 H.sub.15 NO, HCl).sub.n, with a molecular weight (213,7)n.
This is a water-soluble (50 mg/ml) white powder.
The aromatic polyamine has been known since the 50s as a histamine releaser and is used in allergology as reference product in skin tests.
So far, the products of this type have never been proposed for use in prophylactic or curative compositions.
In a surprising and unexpected way it has now been found that the products resulting from the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde such as defined above and hereinafter referred to as "products of the aromatic polyamine-type" can advantageously be used in compositions for the local treatment of the epidermis, especially of the scalp.
More specifically, it has been found that the combined use of the products of the aromatic polyamine type with principles alledgedly active in the epidermic region, increases in a considerable and unexpected way the activity of the latter, and this without undesired side effects while maintaining a localized action.
Generally speaking, the object of the invention is therefore a composition for the local treatment of the epidermis comprising at least two active constituents characterized in that one of these constituents is a product resulting from the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde or product of the aromatic polyamine-type.
The other active constituent is a compound or mixture of compounds known to be more or less active in the application considered.
The composition according to the invention can be adapted to the local treatment of the epidermis on any part of the body, where a cell regeneration is necessary.
According to a particularly advantageous and preferred embodiment, the composition according to the invention is intended for the scalp, in particular for treating alopeciae and alopecia aerata or pelada.
Thus, according to a particular embodiment, the object of the invention is a composition for treating the scalp, particularly for treating alopeciae and alopecia aerata or pelada, characterized in that it includes an efficient amount of proteinic compounds and a non-allergenic amount, although capable of activating the response of the hair follicles, of at least one product resulting from the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde.
According to a preferred embodiment, this composition also contains sulfurized amino acids.
According to an advantageous embodiment of the present invention, the proteinic compounds and as the case may be the sulfurized amino acids are introduced under the form of organic extracts from human or animal origin. They may also be introduced under the form of a mixture of proteins and, if required, of sulfurized amino acids, obtained for example by synthesis or extraction and advantageously used in the proportions observed in the organic extracts.
A particularly suitable organic extract to be used in connection with the present invention is for example the lyophilized "amino proteinic

REFERENCES:
patent: 4193992 (1980-03-01), Fontaine
patent: 4359468 (1982-11-01), Freter et al.
patent: 4542012 (1985-09-01), Dell
patent: 4791217 (1988-12-01), Robert et al.
patent: 4812573 (1989-03-01), Durant et al.
patent: 4835161 (1989-05-01), Janssens et al.

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