Composition for inhibiting adenylate-kinase and its use

Details Composition for inhibiting adenylate-kinase and its use Composition for inhibiting adenylate-kinase and its use

1978-04-13

1980-09-02

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

435 26, 435184, C12Q 150, C12N 999

Patent

active

042207142

ABSTRACT:
A method and a combination of reagents are disclosed for determining the creatine kinase activity by inhibiting the action of creatine kinase, the improvement consisting in that adenosine - 5'- monophosphate is used in combination with an inorganic, preferably an alkali metal, fluoride. By so doing the masking effect of adenylate kinase are efficiently offset.

REFERENCES:
patent: 4042462 (1977-08-01), Johnson et al.
Rosano, et al., "Evaluation of Adenosine 5'-Monophosphate and Fluoride as Adenylate Kinase Inhibitors in the Creative Kinase Assay", Chin. Chem., vol. 22, No. 7, pp. 1078-1083 (1976).
Szasz, et al., "Creative Kinase in Serum: 2. Interference of Adenylate Kinase with the Assay", Clin. Chem., vol. 22, No. 11, pp. 1806-1811 (1976).
Szasz, et al., "Creative Kinase in Serum: 3. Further Study of Adenylate Kinase Inhibitors", Clin. Chem., vol. 23, No. 10, pp. 1888-1892 (1977).
Wilkinson , The Principles and Practice of Diagnostic Enzymology, Year Book Medical Publishers, Inc., Chicago (1976), pp. 96-103.

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