Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1993-09-08
2000-05-09
Saunders, David
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
4241851, 4242751, 424810, 435 724, A61K 3900
Patent
active
06060056&
ABSTRACT:
Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.
REFERENCES:
patent: 4191668 (1980-03-01), Katz
patent: 4220565 (1980-09-01), Katz
patent: 4388441 (1983-06-01), Katz
patent: 4430260 (1984-02-01), Lee et al.
patent: 4650625 (1987-03-01), Pentlow
patent: 4650675 (1987-03-01), Borel et al.
patent: 4722899 (1988-02-01), Hamoaka et al.
patent: 4803070 (1989-02-01), Cantrell et al.
patent: 4863740 (1989-09-01), Kissel et al.
patent: 4950713 (1990-08-01), Katz
patent: 5017648 (1991-05-01), Katz
patent: 5102663 (1992-04-01), Livingston et al.
patent: 5126131 (1992-06-01), Dintzis et al.
patent: 5268454 (1993-12-01), Barstad et al.
patent: 5529922 (1996-06-01), Chapman et al.
patent: 5736146 (1998-04-01), Cohen et al.
Heidenreich et al., "T cell-dependent activity of ganglioside GM1-specific B cells in Guillain-Barre syndrome and multifocal motor neuropathy in vitro" J. Neuroimmunol. (1994) 49:97-108.
Jacobs et al., "Humoral immune response against campylobacter jejuni lipopolysaccharides in Guillain-Barre and Miller Fisher syndrome" J. Neuroimmunol. (1997) 79:62-68.
Johnson et al., "Prolonged and preferential production of polymeric immunoglobulin A in response to streptococcus pneumoniae capsular polysaccharides" Infection and Immunity (1996) 64:4339-4344.
Kronborg et al., "Specific IgG2 antibodies to pseudomonas aeruginosa lipid A and lipopolysaccharide are early markers of chronic infection in patients with cystic fibrosis" Infection (1993) 21:297-302.
Lees et al., "Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate for use in protein-polysaccharide conjugate vaccines and immunological reagents" Vaccine (1996) 14:190-198.
Loizou et al., "Immunoglobulin class and IgC subclass distribution of anticardiolipin antibodies in patients with systemic lupus erythematosus and associated disorders" Clin. Exp. Immunol. (1992) 90:434-439.
Rieben et al., "Naturally occurring ABO antibodies: long-term stable, individually distinct anti-A IgC spectrotypes" Eur. J. Immunol. (1992) 22:2129-2133.
Schreiber et al., "Anti-idiotype-induced, lipopolysaccharide-specific antibody response to pseudomonas aeruginosa" J. Immunol. (1991) 146:188-193.
Stemme et al., "T lymphocytes from human atherosclerotic plaques recognize oxidised low density lipoprotein" Proc. Natl. Acad. Sci. USA (1995) 92:3893-3897.
Watanabe et al., "Detection of immunoglobulin G antibodies to cholesterol in antisera to mycoplasmas" Infection and Immunity (1991) 59:2200-2202.
Willison et al., "Immunoglobulin subclass distribution and binding characteristics of anti-GQ1b antibodies in Miller Fisher syndrome" J. Neuroimmunol. (1994) 50:159-165.
Liu, F-T., et al., "Immunologic tolerance to allertenic protein determinants: properties of tolerance induced in mice treated with conjugates of protein and a synthetic copolymer of .sub.D -glutamic acid and .sub.D -lysine (.sub.D -GL)" J. Immunol. (1979) 123(6):2456-2465.
Butterfield, J.H., et al., "Immunotherapy with short ragweed fraction A: D-glutamic acid: D-lysine polymer in ragweed hay fever" Clin. Immunol. (1981) 67(4):272-278.
Sasaki, T., et al., "Induction of immunological tolerance to single-stranded and double-stranded DNA" Scand. J. Immunol. (1982) 16:191-200.
Sehon, A.H., "Suppression of IgE antibody responses with tolerogenic conjugates of allergens and haptens" Prog. Allergy (1982) 32:161-202.
Wilkinson, I., et al., "Iolerance induction in mice by conjugates of monoclonal immunoglobulins and monomethoxypolyethylene glycol" J. Immunol. (1987) 139(2):326-331.
Borel, H., et al., "A novel technique to link either proteins or peptides to gammaglobulin to construct tolerogens" J. Immunol. Meth. (1990) 126:159-168.
Borel, Y., et al., "Oligonucleotide linked to human gammaglobulin specifically diminishes anti-DNA antibody formation in cultured lymphoid cells from patients with systemic lupus erythematosus" J. Clin. Invest. (1988) 82:1901-1907.
Dintzis, H.M., et al., "Molecular determinants of immunogenicity: the immunon model of immune response" Proc. Natl. Acad. Sci. USA (1976) 73(10):3671-3675.
Dintzis, R.Z., et al., "Studies on the immunogenicity and tolerogenicity of T-independent antigens" J. Immunol. (1983) 131(5):2196-2203.
Dintzis, R.Z., et al., "Inhibition of anti-DNP antibody formation by high doses of DNP-polyacrylamide molecules; effects of hapten density and hapten valence" J. Immunol. (1985) 135(1):423-427.
Dintzis, R.Z., et al., "The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence" J. Immunol. (1989) 143(3):1239-1244.
Lee, W.Y., et al., "Abrogation of reaginic antibodies with modified allergens" Nature (1977) 267:618-619.
Sehon, A.H., "Modulation of antibody responses by conjugates of antigens with monomethoxypolyethylene glycol" Adv. Exp. Med. Biol. (1988) 251:341-351.
Wunsch, E., et al., "Fully synthetic immunogens" Int. J. Peptide Protein Res. (1991) 37:90-102.
Nossal, G.J.V., "Immunologic tolerance: collaboration between antigen and lymphokines" Science (1989) 245:147-153.
Nossal, G.J.V., "Immunologic tolerance" Fundamental Immunology, Paul, W.E., ed., Second Edition, (1989) Raven Press, New York, NY, Chapter 19, pp. 571-586.
Ada, G.L., "The generation of cellular vs. humoral immunity" Synthetic Vaccines, Arnon, R., ed., vol. I, (1987) CRC Press, Inc., Boca Raton, FL, Chapter 3, pp. 25-37.
Habicht, G.S., "Methods for the study of the cellular basis of immunologic tolerance" Immune Response at the Cellular Level, Zacharia, T.P., ed., (1973) Marcel Dekker, Inc., New York, NY., Chapter 6, pp. 141-160.
Francis, M.J., et al., "Peptides with added T-cell epitopes can overcome genetic restriction of the immune response" Vaccines 88, Ginsberg, H., et al., eds., (1988) Cold Spring Harbor Laboratory, pp. 1-7.
De Franco, A., "Tolerance: a second mechanism" Nature (1989) 342:340-341.
Goodnow, C.C., et al., "Induction of self-tolerance in mature peripheral B lymphocytes" Nature (1989) 342:385-391.
Chiller, J.M., et al., "Biography of a tolerant state: Cellular parameters of the unresponsive state induced in adult mice to human gama globulin" Journal of the Reticuloendothelial Society (1975) 17(3):180-186.
Etlinger et al., "Induction of tolerance in athymic mice with an antigen which is highly immunogenic in euthymic mice" Cell. Immunol. (1977) 33:297-308.
A Concise Dictionary of Chemistry, Oxford UP 1990.
Alemany, S. et al. (1987) "Phospho-dephospho-control by insulin is mimicked by a phospho-oligosaccharide in adipocytes," Nature 330, 77-79.
Alvarez, J.F. et al. (1991) "Transport in Isolated Rat Hepatocytes of the Phospho-oligosaccharide that Mimics Insulin Action," Biochem J. 274, 369-374.
Bach, J.F and Viard, J.P. (1990) "Hypothesis: systemic lupus erythematosus as a disease secondary to polyclonal lymphocyte activation," Clin. Exp. Rheumatol. 8 (Suppl. 5), 57-64.
Bennett, R.M. et al. (1992) Idiotypic mimicry of a cell surface DNA receptor: Evidence for anti-DNA antibodies being a subset of anti-anti-DNA receptor antibodies,: Clin. Exp. Immunol. 90, 428-433.
Bock, L.C. et al. (1992) "Selection of single-stranded DNA molecules that bind and inhibit human thrombin," Nature 355, 564-566.
Bootsma, H. et al. (1995) "Prevention of relapses in systemic lupus erythematosus," Lancet 345, 1595-1599.
Burke, J.M. and Berzal-Hernanz, A. (1993) "In Vitro Selection and Evolution of RNA: Applications for Catalytic RNA, Molecular Recognition, and Drug Discovery," FASEB J. 7, 106-112.
Devlin, J.J. (1990) "Random peptide libraries: A source of specific protein binding molecules," Science, 249, 404-406.
Diamond, B. and Scharff, M.D. (1984) "Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity," Proc. Natl. Acad. Sci. USA
Barstad Paul A.
Coutts Stephen M.
Iverson G. Michael
Jones David S.
La Jolla Pharmaceutical Company
Saunders David
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