Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2007-04-24
2007-04-24
Saunders, David A. (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
C424S185100, C424S193100, C424S275100, C424S810000, C530S300000, C530S350000, C530S403000
Reexamination Certificate
active
10081076
ABSTRACT:
Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.
REFERENCES:
patent: 4191668 (1980-03-01), Katz
patent: 4220565 (1980-09-01), Katz
patent: 4388441 (1983-06-01), Katz
patent: 4430260 (1984-02-01), Lee et al.
patent: 4599231 (1986-07-01), Milich et al.
patent: 4650625 (1987-03-01), Pentlow
patent: 4650675 (1987-03-01), Borel et al.
patent: 4722899 (1988-02-01), Hamaoka
patent: 4803070 (1989-02-01), Cantrell et al.
patent: 4863740 (1989-09-01), Kissel et al.
patent: 4886782 (1989-12-01), Good et al.
patent: 4925787 (1990-05-01), Tanihara et al.
patent: 4950469 (1990-08-01), Katz
patent: 4950713 (1990-08-01), Katz
patent: 5017648 (1991-05-01), Katz
patent: 5102663 (1992-04-01), Livingston et al.
patent: 5126131 (1992-06-01), Dintzis et al.
patent: 5162515 (1992-11-01), Conrad et al.
patent: 5177188 (1993-01-01), Ginsberg et al.
patent: 5268454 (1993-12-01), Barstad et al.
patent: 5276013 (1994-01-01), Conrad et al.
patent: 5529922 (1996-06-01), Chapman et al.
patent: 5552391 (1996-09-01), Coutts et al.
patent: 5606047 (1997-02-01), Coutts et al.
patent: 5633395 (1997-05-01), Coutts et al.
patent: 5736146 (1998-04-01), Cohen et al.
patent: 5874409 (1999-02-01), Victoria et al.
patent: 6022544 (2000-02-01), Dintzis et al.
patent: 6060056 (2000-05-01), Coutts et al.
patent: 6207160 (2001-03-01), Victoria et al.
patent: 6340460 (2002-01-01), Dintzis et al.
patent: 6410775 (2002-06-01), Victoria et al.
patent: 6858210 (2005-02-01), Marquis et al.
patent: 2002/0082400 (2002-06-01), Coutts et al.
patent: 2002/0107389 (2002-08-01), Coutts et al.
patent: 2003/0162953 (2003-08-01), Coutts et al.
patent: 2005/0004351 (2005-01-01), Marquis et al.
patent: 2005/0026856 (2005-02-01), Coutts et al.
patent: 2005/0031635 (2005-02-01), Coutts et al.
patent: WO 91/10426 (1991-07-01), None
patent: QO 91/12816 (1991-09-01), None
patent: WO 92/11029 (1992-07-01), None
patent: WO 92/11030 (1992-07-01), None
patent: WO 92/13558 (1992-08-01), None
patent: WO 93/02093 (1993-02-01), None
Alemany et al. (1987). “Phospho-dephospho-control by Insulin is Mimicked by a Phospho-oligosaccharide in Adipocytes,”Nature330:77-79.
Alvarez et al. (1991). “Transport in Isolated Rat Hepatocytes of the Phospho-oligosaccharide that Mimics Insulin Action,”Biochem J. 274:369-374.
Bach, J.F and J.P.Viard. (1990). “Hypothesis: Systemic Lupus Erythematosus as a Disease Secondary to Polyclonal Lymphocyte Activation,”Clin. Exp. Rheumatol. 8 (Suppl. 5):57-64.
Bennett et al. (1992). “Idiotypic Mimicry of a Cell Surface DNA Receptor: Evidence for Anti-DNA Antibodies Being a Subset of Anti-DNA Receptor Antibodies,”Clin. Exp. Immunol. 90:428-433.
Bock et al. (1992). “Selection of Single-Stranded DNA Molecules that Bind and Inhibit Human Thrombin,”Nature355:564-566.
Burke, J.M. and A. Berzal-Hernanz. (1993). “In VitroSelection and Evolution of RNA: Applications for Catalytic RNA, Molecular Recognition, and Drug Discovery,”FASEB J. 7:106-112.
Coulson, E.J. and H. Stevens. (1961). “Some Observations on the Immunochemistry of Dextrans”J. Immunol. 86: 241-252.
Devlin et al. (1990). “Random Peptide Libraries: A Soure of Specific Protein Binding Molecules,”Science249:404-406.
Diamond, B. and M.D. Scharff. (1984). “Somatic Mutation of the T15 Heavy Chain Gives Rise to an Antibody with Autoantibody Specificity,”Proc. Natl. Acad. Sci. USA81:5841-5844.
Diamond et al. (1992). “The Role of Somatic Mutation in the Pathogenic Anti-DNA Response,”Ann. Rev. Immunol. 10:731-757.
Dintzis et al. (1976). “Molecular Determinants of Immunogenicity: the Immunon Model of Immune Response,”Proc. Natl. Acad. Sci. USA73(10):3671-3675.
Etlinger, H. and M. Chiller. (1977). “Induction of Tolerance in Athymic Mice with an Antigen Which is Highly Immunogenic in Euthymic Mice,”Cell. Immunol. 33:297-308.
Finkelman, F.D. (1995). “Cross-linking of Membrane Immunoglobin D, in the Absence of T Cell Help, Kills Mature B CellsIn Vivo,” J. Exp. Med. 181:515-525.
Fulcher et al. (1994). “Whither the Anergic B-Cell?”Autoimmunity19:135-140.
Goodnow, C.C. (1989). “Induction of Self-Tolerance in Mature Peripheral B Lymphocytes,”Nature342:385-391.
Green, D.R. (1983). “Immunoregulatory T-cell Pathways,”Ann.Rev. Immunol. 1:439-463.
Hartley et al. (1993). “Elimination of Self-Reactive B Lymphocyte Proceeds in Two Stages: Arrested Develoment and Cell Death,”Cell72:325-335.
Hefeneider et al. (1993). “Immunization of BALB/c Mice with a Monoclonal Anti-DNA Antibody Induces an Anti-idiotypic Antibody Reactive with a Cell-surface DNA Binding Protein,”Autoimmunity15:187-194.
Holford-Strevens et al. (1982). “Suppression of IgE Antibody Production in Sensitized Mice and Rats by Tolerogenic Conjugates of Synthetic Hydrophilic Polymers with Antigen or Hapten: Effects on Antigen-induced Histamine Release from Peritoneal Mast Cells,”Int. Archs. Allergy Appl. Immunol. 67:109-116.
Hudson et al. (1986). “Cloning and Expression of a Viral Phosphoprotein:Structure Suggests Vesicular Stomatitis Virus NS May Function by Mimicking an RNA Template,”J. Gen. Virol. 67:1571-1579.
Janeway, C.A., Jr. and P. Travers. eds. (1994).Immunobiology: The Immune System in Health and Disease. Garland, London (Table of Contents).
Isenberg, D.A. and Y. Shoenfeld. (1988). “An Analysis of Autoimmunity Through Studies of DNA Antibody Idiotypes,”Autoimmunity1:67-75.
Isenberg et al. (1994). “The Origin, Sequence, Structure, and Consequences of Developing Anti-DNA Antibodies, A Human Perspective,”Arthritis Rheum. 37:169-180.
Jacob, L. and J.P. Viard. (1992). “Anti-DNA Antibodies and Their Relationships with Anti-histone and Anti-nucleosome Specificities,”Eur. J. Med. 1:425-431.
Kato et al. (1990). “Protection of Mice Against the Lethal Toxicity of a Lipopolysaccharide (LPS) by Immunization with Anti-Idiotype Antibody to Monoclonal Antibody to Lipid A fromEikenella corrodensLPS,”Infection and Immunity58(2):416-420.
Kaur et al. (1997). “Topological Analysis of the functional mimicry between a peptide and a carbohydrate moiety,”J. Biol. Chem. 272(9):5539-5543.
Kieber-Emmons et al. (1997). “Peptide Mimicry of Adenocarcinoma-Associated Carbohydrate Antigens,”Hybridoma16(1):3-10.
Lal et al. (1991). “A Synthetic Peptide Elicits Antibodies Reactive with the External Glycoprotein of Human T Cell Lymphotropic Virus Type 1,”J. Gen. Virol. 72:2321-2324.
Livneh, A. (1993). “Anti-DNA Antibodies Secreted by Peripheral B Cells of Lupus Patients Have Both Normal and Lupus-specific Features,”Clin. Immunol. Immunopathol. 68:68-73.
Macaya et al. (1993). “Thrombin-binding DNA Aptamer Forms a Unimolecular Quadruplex Structure in Solution,”Proc. Natl. Acad. Sci. USA90:3745-3749.
Mandrell, R.E. and M.A. Apicella. (1993). “Lipo-oligosaccharides (LOS) of Mucosal Pathogens: Molecular Mimicry and Host-Modification of LOS,”Immunobiol. 187:382-402.
Morimoto et al. (1987). “A Defect of Immunoregulatory T Cell Subsets in Systemic Lupus Erythematosus Patients Demonstrated with Anti-2H4 Antibody,”J. Clin. Invest. 79:762-768.
Mozes, E. and S. Mendlovic. (1990). “The Role of Anti-DNA idiotype Antibodies in Systemic Lupus Erythematosus,”Critical Reviews in Immunology10(4):329-345.
Norman, P.S. (1984). “Immunologic Responses to Conjugates of Antigen E in Pateints with Ragweed Hay Fever,”J. Allergy Clin. Immunol. 73(6):782-789.
Norvell et al. (1995). “Engagement o
Barstad Paul A.
Iverson G. Michael
La Jolla Pharmaceutical Company
Morrison & Foerster / LLP
Saunders David A.
LandOfFree
Composition for inducing humoral anergy to an immunogen... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition for inducing humoral anergy to an immunogen..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition for inducing humoral anergy to an immunogen... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3744376