Composition for improving calcium metabolism

Details Composition for improving calcium metabolism Composition for improving calcium metabolism

1996-05-31

1998-05-26

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

A61K 3159

Patent

active

057564884

ABSTRACT:
A composition for improving calcium metabolism comprising, as an active ingredient, (20S,22R)-22-methyl-1.alpha.,25-dihydroxyvitamin D.sub.3 ; and a method of treating a calcium metabolism disorder in a mammal comprising administering a therapeutically effective amount of (20S,22R)-22-methyl-1.alpha.,25-dihydroxyvitamin D.sub.3.

REFERENCES:
patent: 4929610 (1990-05-01), Meier et al.
J. Nutr. Sci. Vitaminol., vol. 35, pp. 529-533, 1989, Toshio Okano, et al., "Protein-Binding Properties of 22-Oxa-1.alpha.,25-Dihydroxyvitamin D.sub.3, A Synthetic Analogue of 1.alpha.,25-Dihydroxyvitamin D.sub.3 ".
J. Biochem., vol. 115, pp. 373-380, 1994, Tadashi Kobayashi, et al., "The Binding Properties, With Blood Proteins, and Tissue Distribution of 22-Oxa-1.alpha.,25-Dihydroxyvitamin D.sub.3, A Noncalcemic Analogue of 1.alpha.,25-Dihydroxyvitamin D.sub.3, in Rats".
Endocrine Reviews, vol. 16, No. 2, pp. 200-257, 1995, Roger Bouillon, et al., "Structure-Function Relationships in the Vitamin D Endocrine System".

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