Composition for gastrointestinal ulcers

Details Composition for gastrointestinal ulcers Composition for gastrointestinal ulcers

1986-02-04

1988-05-31

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530388, 514925, 514926, 514927, A61K 3700, C07G 700

Patent

active

047481579

ABSTRACT:
Fab or Fc fragment of human IgG which is obtainable by enzymatic digestion of the human IgG is reduced by a reducing agent to sever an interchain of disulfide bonds therein and then blocked the SH radicals formed with alkyl group which may contain other group. The resulting alkylated Fab and Fc fragments display therapeutic and prophylactic action for gastrointestinal ulcers by the oral or parenteral administration.

REFERENCES:
patent: 4330620 (1982-05-01), Gruber et al.
Chem. Abstracts Citation of Mimura et al. Vol. 99 1983 No. 68657u.
Chem. Abstracts Citation of Green Cross Corp., vol. 96:205420r 1982.

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