Composition for forming antithrombotic medical appliances

Details Composition for forming antithrombotic medical appliances Composition for forming antithrombotic medical appliances

1989-10-18

1992-10-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424486, 424422, 424423, 514560, 514822, 514953, 523112, 523113, 604266, A61K 914, A61K 3120, A01N 100

Patent

active

051530031

ABSTRACT:
A composition comprising a polymer having dispersed therethrough a prostacyclin derivative selected from the group consisting of compounds of formula (I): ##STR1## (in which R.sup.1 represents hydrogen or lower alkyl, R.sup.2 represents a C.sub.3 -C.sub.12 alkyl group or a C.sub.3 -C.sub.12 alkenyl group; and n is an integer from 1 to 5; and pharmaceutically acceptable salts thereof) can be used to make a medical appliance from which the prostaglandin, having antithrombotic properties, will be released gradually and in a controlled way.

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patent: 4604412 (1986-08-01), Joh et al.
patent: 4713402 (1987-12-01), Solomon
Plastics in Medicine and Surgery, III, No. 31, 1979, pp. 31.1-31.7; J. C. McRea et al, "Prostaglandin releasing polymers for nonthrombogenic surfaces".

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