Composition for forming antithrombotic medical appliances

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices

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424486, 424422, 424423, 514560, 514822, 514953, 523112, 523113, 604266, A61K 914, A61K 3120, A01N 100

Patent

active

051530031

ABSTRACT:
A composition comprising a polymer having dispersed therethrough a prostacyclin derivative selected from the group consisting of compounds of formula (I): ##STR1## (in which R.sup.1 represents hydrogen or lower alkyl, R.sup.2 represents a C.sub.3 -C.sub.12 alkyl group or a C.sub.3 -C.sub.12 alkenyl group; and n is an integer from 1 to 5; and pharmaceutically acceptable salts thereof) can be used to make a medical appliance from which the prostaglandin, having antithrombotic properties, will be released gradually and in a controlled way.

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Plastics in Medicine and Surgery, III, No. 31, 1979, pp. 31.1-31.7; J. C. McRea et al, "Prostaglandin releasing polymers for nonthrombogenic surfaces".

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