Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Gas produced in situ by chemical reaction
Patent
1991-12-12
1993-04-20
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Gas produced in situ by chemical reaction
424687, 514 23, 514 53, 514 54, 514 60, A61L 904, A61K 3310, A61K 3170, A61K 31715
Patent
active
052040879
ABSTRACT:
A composition for foaming preparation comprising (a) an organic acid of which the crystal surface is coated with a sugar and (b) a carbonate is disclosed. In the composition, an organic acid is completely shut off from a carbonate by a sugar coating so that the acid does not react with the carbonate over a prolonged storage time. When the composition is put into mouth, the sugar which covers the acid is readily dissolved, allowing the acid and the carbonate to react and to generate carbon oxide gas. An excellent foaming calcium preparation can be produced by using calcium carbonate as the carbonate or by adding other salt of calcium to the composition. Such a calcium preparation gives a good taste and favorable feeling upon administration. It is especially suitable for regular administration of calcium over an extended period of time.
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The Merck Index 10 ed. (1983) cit #4852, p. 721.
Saleh, S. I., et al. Expo.-Congr. Int. Technol. Pharm., 3rd (1983) pp. 38-48.
Iwasa Akira
Moroi Masami
Ominato Kimie
Yokoyama Toshio
Henley III Raymond J.
SS Pharmaceutical Co., Ltd.
Waddell Frederick E.
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