Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-03-23
1996-09-03
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514844, 514845, 514873, 564507, A61K 3113
Patent
active
055524451
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to a composition for external skin care which enables the skin to maintain its normal functions and has an effect of curing keratinization and wrinkles of the skin.
BACKGROUND ART
The skin prevents water and other various components in living bodies from being lost. It plays roles of preventing water from dissipating and of constantly maintaining a body temperature. Skin also functions as a barrier for protecting bodies from external physical and chemical stimulators (e.g., humidity, temperature, ultraviolet rays, etc.) and from various bacteria. Its physiological functions in the activities of living bodies are therefore very important. Keeping healthy and beautiful skin is also a subject of a great concern, especially, for female. Conditions of skin, however, are constantly affected by various factors such as humidity, temperature, ultraviolet rays, cosmetics, age, diseases, stress, food customs, and the like. A number of skin troubles, such as deterioration of various skin functions, aging of the skin, and the like, are caused by these factors. Among these, troubles such as dry skin, fatty skin, dandruff, and the like are caused by thickening of the skin, incomplete keratinization, abnormal lipid metabolism, and the like resulting from the progress in turnover of epidermis which is induced by external and internal factors affecting the skin.
Major conventional methods of preventing the skin troubles and improving the skin have been preventing the skin from drying or promoting its moisture retention capability by the application of synthetic or natural moisturizing components, improving blood circulation in the skin by the application of blood circulation promoters, and the like.
These methods, however, involve various problems relating to their effects on the skin trouble prevention or the skin improvement, duration for which the effects last, stability and safety of drugs, and the like.
Development of a composition for external skin care which is safe and has a superior keratin improving effect has therefore been desired.
On the other hand, wrinkles are produced by aging of the skin due to senility, exposure to sun light, and the like. Cells constituting fibroblost synthesizing dermal fiber components decrease and become small due to exposure to sun light and along with age. Especially, a large amount of colagen fibers are lost, leading to dermal degeneration and reduction in the dermal fat organization, and finally to the skin aging. This is a major cause of wrinkles, atony, and loss of flexibility.
A number of compositions and methods have been proposed for suppressing or curing aged skins such as wrinkles and the like (Japanese Patent Laid-open (ko-kai) Nos. 185005/1987, 502546/1987, 72157/1990, 288822/1990, etc.). Most of them, however, are not satisfactory in their effects of wrinkle improvement.
Vitamin A acid has been confirmed to exhibit a wrinkle curing effect [Journal of the American Academy of Dermatology, Vol. 25, No. 2, Part 1, 231-237 (August, 1991); ibid. Vol. 21, No. 3, Part 2, 638-644 (September, 1989); ibid. Vol. 19, No. 1, Part 2, 169-175 (July 1988); ibid. Vol. 15, No. 4, Part 2, (October, 1986)]. Vitamin A acid, however, has problems in its safety; e.g., it induces red spots on the skin, is irritative and teratogenic.
Development of a safe composition for external skin care exhibiting an excellent wrinkle curing effect has therefore been desired.
Some compounds among amine derivatives represented by the following formula (1), ##STR2## (wherein R.sup.4 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, either substituted or unsubstituted by 1 or more hydroxy groups) are known to be useful as an emulsifier [Journal of Colbid and Interface Science, Vol. 64, No. 2, 300-310 (1978), Japanese Patent Laid-open (ko-kai) No. 117421/1979]. It is also know
REFERENCES:
patent: 3766267 (1973-10-01), Zak et al.
patent: 4734277 (1988-03-01), Login
patent: 5194252 (1993-03-01), Hofmann
patent: 5380528 (1995-01-01), Alban et al.
Fujimori Taketoshi
Fujimura Tsutomu
Higuchi Kazuhiko
Imokawa Genji
Kawamata Akira
Dodson Shelley A.
Kao Corporation
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