Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1979-12-05
1983-11-15
Fagelson, Anna P.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 88, 424177, 424180, 424271, 424278, 436530, 260112R, 536 32, 536 43, 536 98, A61K 3935, A61K 39385, A61K 3939, A61K 3172, A61K 3173, A61K 4700
Patent
active
044155522
ABSTRACT:
A water-soluble non-immunogenic carrier, namely carboxymethyl cellulose, is provided which, in attachment to allergens or other haptens, is capable of inducing an immunological tolerance in an individual of a mammalian species to the allergen or hapten. The allergen or hapten is attached to each of a plurality of the carboxyl groups of carboxymethyl cellulose. Tolerance has been induced in mice to three particular haptens, namely 2,4-dinitrophenyl, penicillin G and fluorescein in the specific embodiments of the present invention.
REFERENCES:
patent: 3794630 (1974-02-01), Mullan
patent: 3959080 (1976-05-01), Orth
Orth et al., Angew. Chem. Internat. Edit., vol. 11, No. 4, 1972, pp. 249-260.
Inman, J. of Immunol., vol. 114, 1975, pp. 704-709.
Howard & Courtenay, Eur J. Immunol., vol. 4, 1974, p. 603.
Diener Erwin
Diner Uriel
Fagelson Anna P.
The Governors of the University of Alberta
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