Composition for determining peroxidase-like activity of hemoglob

Details Composition for determining peroxidase-like activity of hemoglob Composition for determining peroxidase-like activity of hemoglob

1985-10-31

1987-06-16

Bashore, S. Leon

Chemistry: analytical and immunological testing

Hemoglobin, myoglobin, or occult blood

422 56, 422 57, 422 58, 422 61, 436904, 435 28, G01N 3122, G01N 3372, C12Q 128

Patent

active

046736549

ABSTRACT:
The invention provides a reagent composition for detecting peroxidase-like activity in aqueous media, particularly for determining occult blood in fecal matter "in-the-bowl". The reagents comprise a dry mixture of a 3, 3', 5, 5' -tetramethylbenzidine and an alkali metal perborate, such as sodium perborate, and preferably also including a strong organic carboxylic acid such as citric acid and a sequesterant for trace metals such as ethylenediaminetetraacetic acid. The composition can be made increasingly more stable by coating the tetramethylbenzidine and an antioxidant with a water soluble polymer and or film coating the sodium perborate with a coating at least partially soluble in water. The reagents are deposited in porous or holed matrices including adsorbent paper, gelatin and molded polysaccharide film.

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patent: 4071318 (1978-01-01), Lam
patent: 4077772 (1978-03-01), Geissler
patent: 4329317 (1982-05-01), Detweiler et al.
patent: 4587100 (1986-05-01), Amano et al.

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