Composition for determination of N-nitrosamines

Details Composition for determination of N-nitrosamines Composition for determination of N-nitrosamines

1980-07-07

1982-06-22

Helfin, Bernard

Compositions

Nonreactive analytical, testing, or indicating compositions

G01N 3100, G01N 3300

Patent

active

043361587

ABSTRACT:
N-nitrosamines are reacted with a denitrosating agent to cleave the N-NO bond and yield nitric oxide which may be analyzed to determine both qualitatively and quantitatively, the N-nitrosamine content of a test sample. The denitrosating reagent has the advantage of being useful, even in the presence of substantial amounts of water, and comprises a mixture of glacial acetic acid and a concentrated inorganic acid which is either phosphoric acid or sulfuric acid. The volume ratio of glacial acetic to concentrated acid is within the ratio of from 1:2 to 5:1. This acid component mixture is combined with from about 0.1% to about 5% by weight of soluble inorganic bromide or iodide salt.

REFERENCES:
patent: 3512937 (1970-05-01), Schulze
patent: 3776697 (1973-12-01), Crawford et al.
patent: 4116633 (1978-09-01), Mia
patent: 4256462 (1981-03-01), Frank et al.
Hickinbottom, Reactions of Organic Compounds (1962) 472-477.
Smith, The Chemistry of Open-Chain Organic Nitrogen Compounds, vol. II (1966) 472-473 and 509.
Belyaev et al., Chem. Abs. vol. 62 (1965) 7606g.

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