Composition for detecting leucocyte and proteinase in urine and

Details Composition for detecting leucocyte and proteinase in urine and Composition for detecting leucocyte and proteinase in urine and

1996-10-25

1998-05-12

Gitomer, Ralph

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 23, C12Q 144, C12Q 137

Patent

active

057503591

ABSTRACT:
With the recognition that like esterase, the thiazole derivatives show a strong nucleophilicity owing to sufficient electronic density in heterocycle, when its ester is degraded by some enzymes. The composition for detecting leucocyte and proteinase in urine has been developed, which contains a thiazole derivative. According to this invention, the thiazole derivative may be synthesized as an ester form by combining both the well-known thiazolone derivative and amino acid derivatives as starting materials. Now that the method for manufacturing the thiazole derivative is simple and general, the mass-scale production may be available within a short period of time. Further, in case of the measuring device produced according to this invention, the application method is simple and diagnostic performance is superior.

REFERENCES:
patent: 4657855 (1987-04-01), Corey et al.
patent: 5464739 (1995-11-01), Johnson et al.

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