Composition for delivery of toxic radioisotopes to the cell nucl

Details Composition for delivery of toxic radioisotopes to the cell nucl Composition for delivery of toxic radioisotopes to the cell nucl

1996-08-01

1998-06-02

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 424 173, A61K 5100, A61M 3614

Patent

active

057595143

ABSTRACT:
A conjugate of a tumor cell-targeting protein or polypeptide and a nucleic acid-targeting small molecule labeled with an Auger electron-emitting radionuclide is useful for tumor therapy. The tumor cell-targeting protein or polypeptide may be an antibody or fragment thereof, a hormone or a growth factor.

REFERENCES:
patent: 4547569 (1985-10-01), Letsinger et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4757072 (1988-07-01), Kabbe et al.
patent: 4894348 (1990-01-01), Ronald et al.
patent: 5057313 (1991-10-01), Shih et al.
patent: 5059413 (1991-10-01), Reardan et al.
patent: 5096694 (1992-03-01), Quivy et al.
patent: 5130116 (1992-07-01), Woo et al.
patent: 5175273 (1992-12-01), Bischofberger et al.
patent: 5332567 (1994-07-01), Goldenberg
Pittman et al., Biochem. Journal, vol. 212, pp. 791-800, 1983.
Shih, Lisa B. et al., "The Processing and Fate of Antibodies and Their Radiolabels Bound to the Surface of Tumor Cells in Vitro: A Comparison of Nine Radiolabels", The Journal of Nuclear Medicine, vol. 35, No. 5, pp. 899-908 (May 1994).
Kyriakos, Raymond J. et al., "The Fate of Antibodies Bound to the Surface of Tumor Cells in Vitro", Cancer Research, 32, pp. 835-842 (Feb. 1992).
Cowan, D.S.M. et al., "Targeting Radiosensitizers to DNA by Attachment of an Intercalating Group: Nitroimidazole-Linked Phenanthridines", Radiation Research, 127, pp. 81-89 (1991).
Kinsey, Berma M. et al., "Synthesis and Biological Activity of the Nucl. Med. Biol., vol. 17, No. 3, pp. 341-346 (1990).
Roberts, Peter B. et al., "Hypoxia-selective radiosensitization of mammalian cells by nitracrine, an electron-affinic DNA Intercalator", Int. J. Radiat. Biol., vol. 51, No. 4, pp. 641-654 (1987).
Martin, Roger F. et al., "Cytotoxicity of an .sup.125 I-labled DNA-binding Compound That Induces Double-Stranded DNA Breaks", Cancer Research, 39, pp. 3244-3247 (Aug. 1979).
Adams, Adrienne et al., "Interaction of DNA-Intercalating Antitumor Agents with Adrenoceptors", Molecular Pharmacology, 27, pp. 480-491 (1985).
Warters, R.L. et al., "Radionuclide Toxicity in Cultured Mammalian Cells: Elucidation of the Primary Site of Radiation Damage", Current Topics in Radiation Research Quarterly, 12, pp. 389-407 (1977).
Martin, Roger F., "Induction of double-stranded breaks in DNA by binding with an .sup.125 I-labelled acridine", Int. J. Radiat. Biol., vol. 32, No. 5, pp. 491-497 (1977).

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