Composition for controlling hemophilia in mammals

Details Composition for controlling hemophilia in mammals Composition for controlling hemophilia in mammals

1985-02-06

1986-09-09

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

514 76, 514 77, 514 78, 514785, 514786, A61K 3514

Patent

active

046108807

ABSTRACT:
A composition of matter for controlling Hemophilia A (Antihemophilic Factor (F. VIII:C) deficiency) in mammals is described. Factor VIII:C deficiency in the mammal is bypassed by infusion of a synergistic mixture of a phospholipid and Factor Xa so that the cascade process of blood clotting may continue. The proportions of phospholipid and Factor Xa in the mixture are critical as too little Xa has no effect while too much is toxic (thrombogenic).

REFERENCES:
Giles et al.--Blood, vol. 59, No. 2, (Feb. 1982) pp. 401-407.

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