Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1985-10-18
1988-08-16
Griffin, Ronald W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
436 93, 436 94, 436131, 436172, 436174, 436161, 422 70, 2101982, 73 611C, 514 26, A61K 3170, C07J 1900
Patent
active
047646012
ABSTRACT:
A fluorescent compound is made from the reaction of naphthoyl chloride and a cardiac glycoside derived from serum or plasma. The method of carrying out the reaction provides a product which allows for a 100-fold increase in sensitivity when the product is subjected to chromatographic analysis according to the described apparatus.
REFERENCES:
patent: 4184037 (1980-01-01), Wilkinson
patent: 4555504 (1985-11-01), Jones
Abstract Assay of Digoxin and Metabolites in Urine and Feces by HPLC of Fluorescent Derivatives, Theresa Shepard and Richard H. Reuning, College of Pharmacy, OSU, Columbus, OH 43210, p. 647, World Conference on Clinical Pharmocology Therapeutics, Washington, D.C., Jul. 31-Aug. 5, 1983.
I. Methods for Digoxin and Metabolite Determination in Urine, Feces and Plasma and Application to Detection of R-Dihydrodigoxin in Humans and II. A Theroretical Examination of the Kinetics of Enterohepatic Cycling, by Theresa A. Shepard, Ph.D. The Ohio State University, 1983 Professor Richard H. Reuning, Advisor.
Hui James
Reuning Richard H.
Sams Richard A.
Shepard Theresa A.
Griffin Ronald W.
Millard Sidney W.
The Ohio State University Research Foundation
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