Composition for assaying cardiac glycosides from serum or plasma

Details Composition for assaying cardiac glycosides from serum or plasma Composition for assaying cardiac glycosides from serum or plasma

1985-10-18

1988-08-16

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

436 93, 436 94, 436131, 436172, 436174, 436161, 422 70, 2101982, 73 611C, 514 26, A61K 3170, C07J 1900

Patent

active

047646012

ABSTRACT:
A fluorescent compound is made from the reaction of naphthoyl chloride and a cardiac glycoside derived from serum or plasma. The method of carrying out the reaction provides a product which allows for a 100-fold increase in sensitivity when the product is subjected to chromatographic analysis according to the described apparatus.

REFERENCES:
patent: 4184037 (1980-01-01), Wilkinson
patent: 4555504 (1985-11-01), Jones
Abstract Assay of Digoxin and Metabolites in Urine and Feces by HPLC of Fluorescent Derivatives, Theresa Shepard and Richard H. Reuning, College of Pharmacy, OSU, Columbus, OH 43210, p. 647, World Conference on Clinical Pharmocology Therapeutics, Washington, D.C., Jul. 31-Aug. 5, 1983.
I. Methods for Digoxin and Metabolite Determination in Urine, Feces and Plasma and Application to Detection of R-Dihydrodigoxin in Humans and II. A Theroretical Examination of the Kinetics of Enterohepatic Cycling, by Theresa A. Shepard, Ph.D. The Ohio State University, 1983 Professor Richard H. Reuning, Advisor.

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