Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1995-11-27
1998-02-10
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424401, 424 63, 264 41, 264 43, A61K 9127
Patent
active
057166382
ABSTRACT:
A cosmetic or medical composition for topical application to the skin. It results in the transdermal passage of an active ingredient, or in the introduction of such agent into the skin. The essential components of such compositions are phospholipids, an aliphatic alcohol of three or four carbon atoms or a combination of these alcohols, water and a compatible active ingredient, optionally with propylene glycol. Compositions advantageously comprise from 0.5% to 10% phospholipids, from 5% to 35% of a C.sub.3 - or C.sub.4 -alcohol, 15 to 30% ethanol, which contain together at least 20% but not more than 40 wt. % of ethanol and the C.sub.3 -alcohol; up to 20 wt. % propylene glycol, at least 20% water and at least one active ingredient. The compositions are suitable for the topical application of a wide variety of cosmetic and pharmaceutically active compounds. Phospholipids of choice are phosphatidylcholine, (P C), hydrogenated P C, phosphatidic acid (P A), phosphatidylserine (P S), phosphatidylethanolamine (P E), phosphatidylglycerol (P P G) and phosphatidylinositol (P I).
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Kishore Gollamudi S.
Yissum Research Development Company of The Hebrew University of
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