Composition for antagonizing the narcotic effects of barbiturate

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424255, 424263, 424266, A61K 31505

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040483169

ABSTRACT:
The invention is based on the discovery, after long study and many test operations, that the combination of five chemical elements, towit 5-hydroxymethylcytosine, thymine, nicotamide, pyridoxal, and thiamine, is effective in antagonizing the narcotic effects of barbiturates, and that each one is essential, in the combination, for positive result. Although thymine per se long has been known as increasing the action of barbiturates, tests of the said composition established that thymine has an unexpected and essential function therein, its omission rendering the composition ineffective. These tests were directly made by the present applicant, with corroboration as to every detail thereof by the Chief of the Section of Neurochemistry, New York State Institute of Neurochemistry and Drug Addiction, established by the State of New York, and operating under its control.

REFERENCES:
patent: 3773955 (1973-11-01), Pacter et al.
Nakagawa, Chemical Abstracts 54:21390a (1960).
Wenzel et al., Chemical Abstracts 49:4177d (1955).
Batt, Chemical Abstracts 55:10580e (1961).
Batt, Chemical Abstracts 55:17760 (1961).
Miller, Chemical Abstracts 49:8302i (1955).
Merck Index, 8th Edition, (1968), pp. 729, 892, 1036 and 1050.

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