Composition for and treatment of inflammatory bowel disease by c

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 111, A61K 3170

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active

060461799

ABSTRACT:
This invention relates to a novel composition and a novel method of treating inflammatory bowel disease (IBD). More particularly, this invention pertains to a novel composition containing N-acetyl-glucosamine (NAG) as an active IBD treating agent and a pharmacologically suitable carrier, and a method of administering the composition to the colon to treat IBD in a person afflicted with IBD. A composition for treating inflammatory bowel disease in a patient suffering from inflammatory bowel disease comprising: (a) a therapeutic amount of N-acetyl-glucosamine; and (b) a pharmacologically acceptable carrier, adapted to be administered colonically to said patient.

REFERENCES:
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patent: 5217962 (1993-06-01), Burton et al.
patent: 5229374 (1993-07-01), Burton et al.
Burton, A.F. and Anderson, F.H., Decreased Incorporation of .sup.14 C-Glucosamine Relative to .sup.3 H-N-Acetyl Glucosamine in the Intestinal Mucosa of Patients with Inflammatory Bowel Disease. American Journal of Gastroenterology, vol. 78, No. 1, 1983.
Vantrappen, G. and Geboes, K. Glycosaminoglycans and the gut. Lancet 341: 730, 1993.
Murch, S.H. et al., Disruption of sulphated glycosaminoglycans in intestinal inflammation. Lancet 341: 711, 1993.
Murch, S.H., et al., Congenital enterocyte heparan sulphate deficiency with massive albumin loss, secretory diarrhoea, and malnutrition. Lancet 347: 1299, 1996.
Murch, S.H., Sulphation of proteoglycans and intestinal function. J. Gastroenterol. Hepatol. 10: 210, 1995.
Pender, Sylvia L.F., et al., A Major Role for Matrix Metalloproteinases in T Cell Injury in the Gut. J. Immunol. 1997; 158: 1582-1590.

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