Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1986-04-28
1989-05-02
Rollins, John W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514468, 514691, 514729, 514866, A61K 3578, A61K 3134, A61K 3112, A61K 31045
Patent
active
048266841
ABSTRACT:
A method of producing a composition for use in the treatment of insulin-dependent diabetes is described. The active ingredient in the composition is a mixture of terpenoids derived from an extract of the tubers of the plant Cyperus rotundus Linn and is administered orally to diabetic patients to provide therapeutic effects such as reducing blood sugar levels. The prepared extract can be in a powder form or in a volatile oil. A comparison of oral administration of equal volumes of the composition and insulin indicates that the composition has about 20% of the effect of insulin, which would be obviated by concentrating the composition. The composition can also be administered parenterally. In clinical trials on humans a flavor enhanced composition derived from an agneous-based paste resulted in significant therapeutic benefit with no side effects.
The production of the composition and method of treatment of a diabetic patient is also described.
REFERENCES:
patent: 4569843 (1986-02-01), Kim
Chem. Abst. 88:51025m 1978.
Chem. Abst. 93:235161n, 1980.
Chem. Abst. 88:86013h, 1978.
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