Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1975-03-18
1977-05-10
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 94, A61K 3700
Patent
active
040228835
ABSTRACT:
The invention concerns an orally administered composition, i.e. a medically active agent for alleviation of uremic symptoms and a method for its preparation. The invention is based on the surprising observation that non-protein nitrogen compounds which accumulate in the body of uremic patients herein referred to as (NPN compounds: in the literature often designated as "uremia toxines") may be biodegraded and biosynthetized to harmless metabolites by utilizing selected non-pathogenic soil microorganisms, as a result of the action of these microorganisms in the intestine of the patient. In this way, at least part of the NPN compounds may be non-toxified, i.e., utilized by the organism. It is also observed that the NPN compounds, as such, do not represent any worthless "waste products" which necessarily have to be excreted. Instead only an excess of NPN not required and not utilized is excreted under normal circumstances. Further, the NPN:s do not constitute "end products" but are potentially valuable intermediates which allow a so called shuttle traffic in the internal metabolism, in other words: synthesis .revreaction. degradation .revreaction. resynthesis. In order to prevent an excess enrichment of unwanted NPN compounds in the body of patients suffering from irreversible progressive renal failure, the processes responsible for the internal metabolism must be "cycled backwards".
REFERENCES:
patent: 3701830 (1972-10-01), Weinrich et al.
patent: 3865726 (1975-02-01), Chibata et al.
Bioscal GmbH
Waddell Frederick E.
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