Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-07-08
1989-08-29
Dixon, Jr., William R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514345, 514346, 514869, A61K 3164
Patent
active
048617865
ABSTRACT:
The present invention provides an aqueous, alkaline injection solution of torasemide ready for injection, which contains a physiologically compatible alkaline buffer with a pH value of from 9.3 to 9.9 and with a buffer capacity of up to 0.1 val/liter together with an organic solvent in an amount of from 5 to 20% by weight selected from the group of polyethylene glycols with a molecular weight of from 100 to 1500, polypropylene glycols with a molecular weight of from 50 to 1000, glycerol, propylene glycol, ethanol and propanol, the torasemide being present in a concentration of from 2 to 40 mg/ml. Torasemide solutions are useful to inhibit inflammation or promote diuresis.
The present invention also provides a process for the preparation of this solution, wherein torasemide is suspended in the above organic solvent brought into solution by the addition of aqueous alkali, adding the buffer and other adjuvants and adjusting the pH value to 9.3 to 9.9.
REFERENCES:
patent: 4020162 (1977-04-01), Ghilardi et al.
patent: 4301160 (1981-11-01), Leeb et al.
patent: 4711906 (1987-12-01), Vonstetten
patent: 4743693 (1988-05-01), Topfmeier et al.
Arzneimittel Forschung/Drug Research, Band 35 (II) Oct. 1985.
Remington's Pharmaceutical Sciences, Chapter 84, 1980 1466-1468, pp. 1532-1535.
Demmer Fritz
Gruber Werner
Woog Heinrich
Boehringer Mannheim GmbH
Dixon Jr. William R.
Johnson Jerry D.
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