Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2005-08-09
2005-08-09
Prouty, Rebecca E. (Department: 1652)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C435S226000, C530S380000, C536S023500
Reexamination Certificate
active
06926894
ABSTRACT:
The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV (SEQ ID NO: 1), vWF cleaving complexes and methods for their production.
REFERENCES:
Furlan M. et al. Partial Purification and Characterization of a Protease from Human Plasma Cleaving von Willebrand Factor to Fragments Produced by in Vivo Proteolysis, Blood, 1996, 10, 4223-4234.
Gerritsen H. et al. Partial amino acid sequence of purified von Wilebrand factor-cleaving protease, Blood, 2001, 98, 1654-1661.
Zheng X. et al. Structure of von Willebrand Factor-cleaving Protease (ADAMTS13), a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura, J. Biol. Chem. 2001, 276, 41059-41063.
Antoine Gerhard
Furlan Miha
Gerritsen Helena Elisabeth
Kerschbaumer Randolf
Laemmle Bernhard
Baxter Aktiengesellschaft
Prouty Rebecca E.
Townsend and Townsend / and Crew LLP
Walicka Malgorzata A.
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