Composition exhibiting a von willebrand factor (vWF)...

Details Composition exhibiting a von willebrand factor (vWF)... Composition exhibiting a von willebrand factor (vWF)...

2011-03-22

2011-03-22

Hutson, Richard G (Department: 1652)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

C435S226000, C435S183000, C530S380000

Reexamination Certificate

active

07910094

ABSTRACT:
The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.

REFERENCES:
patent: 6579723 (2003-06-01), Mitterer et al.
patent: 6926894 (2005-08-01), Laemmle et al.
patent: 2001/0049106 (2001-12-01), Buckbinder et al.
Furlan M. et al. “Partial Purification and Characterization of a Protease From Human Plasma Cleaving von Willebrand Factor to Fragments Produced by In Vivo Proteolysis.”Blood(May 15, 1996), 87(10):4223-4234.
Gerritsen, H. et al. “Partial amino acid sequence of purified von Willebrand factor-cleaving protease.”Blood(Sep. 15, 2001), 98(6):1654-1661.
Zheng, X. et al. “Structure of von Willebrand Factor-cleaving Protease (ADAMTS13), a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura.”J. Biol. Chem. (Nov. 2, 2001), 276(44):41059-41063.
NCBI Entrez Nucleotide Sequence Report: NM—139025, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=21265033.
NCBI Entrez Nucleotide Sequence Report: NM—139026, http:www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=21265042.
NCBI Entrez Nucleotide Sequence Report: NM—139027, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=21265045.
NCBI Entrez Nucleotide Sequence Report: NM—139028, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=21265048.

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