Composition, device and method of assaying for a peroxidatively

Details Composition, device and method of assaying for a peroxidatively Composition, device and method of assaying for a peroxidatively

1990-01-30

1992-02-18

Hill, Jr., Robert J.

Chemistry: analytical and immunological testing

Hemoglobin, myoglobin, or occult blood

422 56, 435 28, 435805, 436169, 436175, 436904, G01N 2178, G01N 3372

Patent

active

050894200

ABSTRACT:
A new and improved test device and method of determining the presence or concentration of a peroxidatively active substance, such as hemoglobin, in a test sample are disclosed. The test device includes a test pad comprising a suitable carrier matrix incorporating an indicator reagent composition capable of interacting with a perioxidatively active substance to produce a detectable or measurable response. In addition, a new and improved indicator reagent composition, comprising an indicator dye, such as a redox indicator, like a benzidine indicator; a hydroperoxide; an amine borate compound having the general structural formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are, independently, methyl groups or ethyl groups, and m, n and p are numerals ranging from one to about three; a buffer, is incorporated into a suitable carrier matrix to provide a more accurate and trustworthy assay of a test sample for a peroxidatively active substance. The improved method and composition are especially useful in the assay of urine for occult blood.

REFERENCES:
patent: 3853471 (1974-12-01), Rittersdorf et al.
patent: 4071318 (1978-01-01), Lam
patent: 4071321 (1978-01-01), Lam
Steinberg et al., JACS, vol. 82, No. 4, pp. 853-859, 02/1960.

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