Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Aftertreated solid synthetic organic polymer
Patent
1994-11-14
1998-04-07
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Aftertreated solid synthetic organic polymer
A61K 3108
Patent
active
057365806
ABSTRACT:
An electrotransport drug-containing composition is provided. The composition includes a drug to be delivered through a body surface (eg, skin) of a patient, and a permeation enhancer which is solid or semisolid at temperatures typically encountered during storage of pharmaceuticals (eg, temperatures up to at least about 25.degree. C.). The composition of the invention may be applied from a device 10 suitable for electrotransport delivery. A method for increasing electrotransport agent delivery rate and reducing body surface resistance relies on applying the composition of the invention to the body surface, and applying an electric current through the composition and the body surface.
REFERENCES:
patent: 4605670 (1986-08-01), Kenichiro et al.
patent: 4722720 (1988-02-01), Sanderson et al.
patent: 5023085 (1991-06-01), Francoeur et al.
patent: 5084241 (1992-01-01), Mathiesen et al.
patent: 5087242 (1992-02-01), Petelenz et al.
patent: 5128376 (1992-07-01), Saito et al.
patent: 5158537 (1992-10-01), Haak et al.
patent: 5310404 (1994-05-01), Gyory et al.
Database WPI, Section Ch, Week 9408, Derwent Publications Ltd., London, GB; p. P34, AN 94-061979 & JP, A, 06 016 538 (Japan Tobacco Inc.) see abstract.
Wong et al., Pharmaceutical Research, vol. 6, No. 4, 1989, "New Alkyl N,N-Dialkyl-Substituted Amino Acetates as Transdermal Penetration Enhancers".
Wong et al., Internation Journal of Pharmaceutics, vol. 52, (1989), pp. 191-202, "Unsaturated cyclic urea s new non-toxic biodegradable transdermal penetration enhancers. II. Evaluation Study".
Wong et al., Journal of Pharmaceutical Sciences, vol. 77, No. 11, Nov. 1988, pp. 967-971, Unsaturated cyclic Ureas as New Nontoxic Biodegradable Transdermal Penetration Enhancers I: Synthesis.
Pfister, William R., et al., Pharmaceutical Technology, Oct. 1990, pp. 54-60, "Permeation Enhancers Compatible with Transdermal Drug Delivery Systems: Part II: System Design Considerations".
Rolf et al. (Sep. 1988) Pharmaceutical Technology, pp. 130-140, "Chemical and Physical Methods of Enhancing Transdermal Drug Delivery".
Cullander, (1992) Advanced Drug Delivery Reviews, 9: 119-135, "What are the pathways of iontophoretic current flow through mammalian skin?".
Barry, (1987), Journal of Controlled Release, 6: 85-97, "Mode of Action of Penetration Enhancers in Human Skin".
Del Terzo, et al., Pharmaceutical Research, vol. 6, No. 1, (1989), "Iontophoretic Transport of a Honologous Series of Ionized and Nonionized Model Compounds: Influence of Hydrophobicity and Mechanistic Interpretation".
Hirvonen, et al., Proceed, Intern. Symp. Control. Rel. Bioact. Mater., 19 (1992), Controlled Release society Inc., "Transdermal Permeation of Model Anions and Cations; Effect of SkinCharge, Iontophoresis and Penetration Enhancers".
Behl, et al., Journal of Pharmaceutical Sciences, vol. 78, No. 5, pp. 355-360 (1989), "Iontophoretic Drug Delivery: Effects of Physicochemical Factors on the Skin Uptake of Nonpeptide Drugs".
Kontturi, et al., Pharmaceutical Research, vol. 10, No. 3, 1993, pp. 381-385, "Electrochemical characterization of Human Skin by Impedance Spectroscopy: The Effect of Penetration enhancers".
Yu, et al., Drug Development and Industrial Pharmacy, 17 (14),pp. 1905-1930 (1991), "Transdermal dual-Controlled delivery of Testosterone and Estradiol: (II) Enhanced Skin Permeability and Membrane-Moderated Delivery".
Chandrashekar, et al., Indian Journal of Pharmaceutical Sciences, 1994, 56(6), pp. 205-209, "Optimization of Parameters for Transdermal Permeation of Insulin".
Hcaplus 115: 239573 (1991). Yun et al.
Cormier Michel
Huntington James A.
Alza Croporation
Fay Zohreh
Miller D. Bryon
Rogers Christopher P.
Stone Steven F.
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