Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Stabilized enzymes or enzymes complexed with nonenzyme
Patent
1986-09-10
1989-06-06
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Stabilized enzymes or enzymes complexed with nonenzyme
424 941, 424 9464, 435212, 435215, 435217, 435188, 514 21, 514970, 530354, A61R 37547
Patent
active
048370223
ABSTRACT:
A composition containing a tissue Plasminogen Activator (tPA) which comprises a partial hydrolyzate of gelatin cross-linked to a diisocyanate as an essential ingredient; or alternatively a partial hydrolyzate of gelatin cross-linked to a diisocyanate and one or more of a basic amino acid or salt thereof. The composition enhances the solubility of the tPA in water, thereby making the tPA further available in the treatment of circulatory diseases caused by thrombi.
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Murakami et al., CA vol. 104, 1986, #213259u.
Murakami et al., CA vol. 102, 1985 #58407d.
Asakawa Naoki
Ishibashi Yasuo
Kakimoto Fumio
Miyake Yasuo
Draper Garnette D.
Eisai Co. Ltd.
Phillips Delbert R.
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