Composition containing the P40 subunit of interleukin-12

Details Composition containing the P40 subunit of interleukin-12 Composition containing the P40 subunit of interleukin-12

1994-04-29

1996-08-20

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 721, 435 4, 530351, 424 852, C12Q 102, G01N 33567, A61K 4505

Patent

active

055478522

ABSTRACT:
The present invention relates to a composition containing the p40 subunit of interleukin-12, hereinafter referred to as p40/IL-12 and to methods of diagnosis and treatment of disorders associated with disregulation of the immune system.

REFERENCES:
patent: 5296353 (1994-03-01), Ochoa et al.
Ling et al. "Demonstration of The Roles of IL-12 Subunits In Receptor Binding & Signal Transduction" J Immunol. 150(8 Pt 2) 207A. Abstract 1182 1993.
Mattner et al. "The Interleukin-12 subunit P40 Specifically Inhibits Effects of The Interleukin-12 Heterodimer" Eur J. Immunol. 23 2202-2208 1993.
Gubler et al. "Studies On The Expression of Interleukin-12 Subunit mRNAs In Mice" J Cell. Biochem. Supplement 17B 112 Abstract E510 1993.
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Podlaski et al., "Molecular Characterization Of Interleukin 12", Archives Of Biochemistry And Biophysics, vol. 294:230-237, (1992).
Zettlmeissl et al., "Efficient Expression System For Human Antithrombin III In Baby Hamster Kidney Cells", Behring Inst. Mitt., vol. 82:26-34, (1998).
Koehler et al., "Continuous Cultures Of Fused Cells Secreting Antibody Of Predefined Specificity", Nature, vol. 256:495-497, (1975).
Mengel et al., "An Activated Murine B Cell Lymphoma Line (A-20) Prodices A Factor-like Activity Which Is Functionally Related To Human Natural Killer Cell Stimulatory Factor", Eur. J. Immunol., vol. 22:3173-3178, (1992).
Dunn et al., "An Alternative Pathway Of Induction Of Lymphokine Production By T Lymphocyte Clones", The Journal Of Immunology, vol. 142:3847-3856, (1989).

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