Composition containing selegiline

Details Composition containing selegiline Composition containing selegiline

1996-12-27

1998-10-06

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

514654, A61K 920, A61K 31135, A61K 3113

Patent

active

058173366

ABSTRACT:
A new stable solid composition suitable for oral administration comprising a pharmaceutically acceptable acid addition salt of selegiline is achieved by reducing the destabilizing effect of the conventional lubricant present in such compositions, magnesium stearate either by replacing all or a substantial part of the magnesium stearate by other lubricants such as fatty acid esters and vegetable oils and/or by adding a pharmaceutically acceptable acid to the selegiline-containing tablets.

REFERENCES:
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patent: 5057321 (1991-10-01), Edgren et al.
patent: 5128145 (1992-07-01), Edgren et al.
patent: 5151449 (1992-09-01), Milgram
patent: 5192550 (1993-03-01), Edgren et al.
patent: 5192808 (1993-03-01), Ruehl et al.
patent: 5276057 (1994-01-01), Milgram et al.
patent: 5382601 (1995-01-01), Nurnberg et al.
patent: 5384312 (1995-01-01), Schirlin et al.
patent: 5387615 (1995-02-01), Milgram et al.
Lewis et al EXPO Congr. Int. Technol. Pharm. 3rd vol. 5 12-20 (1983) Hydrogenated Costa Oil to Replace Stearic Acid Stearate pp. 39-40.
Kalantzis et al GA. 117:137531 (p. 34) of Pharmakeutike 5(1):35-40 1992 Sodium Benzoate.
Edgren et al CA. 116:46325 of U.S. 5057321 (101591) p. 35 Ethoxylated Castor Oil.
Gross et al GA.114: 150U86 of Pharm. Acta Helv. 66(1):11-15(1991) pp. (35-36) Sodium Benzoate.
Daunora GA. 97: 203230 of U.S. 4347235 Aug. 31, 1982 p. 40 PEG/Na Propionate.
Johnson & Johnson CA. 85.99195 of Jpn 51019116 (21676) p. 40 PEG.
Oldani et al CA. 74: 15733 of Ger DE 2019658 (Nov. 5, 1970). p. 41 PEG.

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