Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2005-02-23
2008-10-07
Kumar, Shailendra (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S623000, C514S624000, C514S625000, C514S626000, C514S629000
Reexamination Certificate
active
07432302
ABSTRACT:
Proliferative cutaneous disease states or conditions are treated by administering a polyamine transport inhibitorin-line-formulae description="In-line Formulae" end="lead"?R-X-L-polyaminein-line-formulae description="In-line Formulae" end="tail"?wherein R is a straight or branched C10-50 saturated or unsaturated aliphatic, carboxyalkyl, carbalkoxyalkyl, or alkoxy; a C1-8 alicyclic; a single or multiring aryl substituted or unsubstituted aliphatic; and aliphatic-substituted or unsubstituted single or multiring aromatic; a single or multiring heterocyclic; a single or multiring heterocyclic aliphatic; an aryl sulfonyl;X is —CO—, —SO2—, or —CH2—; andL is a covalent bond or a naturally occurring amino acid, lysine, ornithine, 2,4-diaminobutyric acid, or pharmaceutically acceptable salts thereof or prodrug thereof, and a polyamine biosynthesis inhibitor.
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□□Golub, Science, vol. 286, 1999, pp. 531-537.□□.
Huff, J. Med. Chem., 34(8), 2305-14, 1991.
Baindur Nand
Burns Mark R.
Graminski Gerard F.
Weeks Reitha S.
Connolly Bove & Lodge & Hutz LLP
Kumar Shailendra
MediQuest Therapeutics, Inc.
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