Composition containing PGI.sub.2 analogs stabilized

Details Composition containing PGI.sub.2 analogs stabilized Composition containing PGI.sub.2 analogs stabilized

1978-05-02

1984-10-30

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424285, 536103, 549465, C07D307395, A61K 3172

Patent

active

044799446

ABSTRACT:
Compositions which contain a PGI.sub.2 analogue in solution in a solvent consisting of at least one pharmacologically-acceptable alcohol, polar aprotic solvent or middle chain triglyceride, or which are cyclodextrin clathrates of a PGI.sub.2 analogue stabilise the PGI.sub.2 analogues against decomposition. They are useful in the treatment of arteriosclerosis, cardiac failure or thrombosis.

REFERENCES:
patent: 4070537 (1978-01-01), Hayashi et al.
patent: 4232009 (1980-11-01), Hayashi et al.
Johnson et al., J.A.C.S., 99:12, Jun. 8, 1977, pp. 4182-4184.
Corey et al., J.A.C.S., 99:6, Mar. 16, 1977, pp. 2006-2008.

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