Composition containing peptides and nucleic acids and methods of

Details Composition containing peptides and nucleic acids and methods of Composition containing peptides and nucleic acids and methods of

1996-10-07

1998-12-15

Elliott, George C.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

424520, 424529, 424535, 514 2, 514 7, 514 44, B01D 6124, A61K 3514, A61K 3520, A61K 3572

Patent

active

058491961

ABSTRACT:
An improved composition containing peptides and nucleic acids has active components, i.e., which heighten the phagocytic activity f neutrophils, consisting of molecules with a molecular weight of at least 8 kDa, and preferably at least 15 kDa. The active components comprise peptides without aromatic portions and will absorb light at an absorption band of .DELTA..lambda.=200-235 mn, .lambda..sub.max =205 nm, in the UV spectrum. The composition is nontoxic and is formulated using casein, blood albumin, beef peptone, nucleic acid (RNA) and a base such as sodium hydroxide. The composition stimulates phagocytic activity of neutrophils if used at sufficient concentrations. A separate composition is obtained using the same components of manufacture, but filtering or centrifuging the composition to a molecular weight of <8-15 kDa which inhibits phagocytic activity of neutrophils for application in treating auto immune diseases.

REFERENCES:
patent: 5539082 (1996-07-01), Nielsen et al.
Hanvey et al. "Antisense and Antigene Properties of Petide Nucleic Acids" Science 258: 1481-1485, Nov. 1992.
Nielsen et al. "Peptide Nucleic Acid (PNA). A DNA Mimic wiht a Peptide Backbone" Bioconjugate Chem. 5: 3-7, Feb. 1994.
Nielsen et al. "Peptide Nucleic Acids (PNAs): Potential Antisense and Anti-Gene Agents." Anti-Cancer Drug Design 8: 53-63, Aug. 1993.
"Peptide Nucleic Acids Stimulate Gamma Interferon and Inhibit the Replication of the Human Immunodeficiency Virus", by Shalom Z. Hirschman and Chey Wei Chen, in Journal of Investigative Medicine, vol. 44, No. 6, Aug. 1996, pp. 347-351.
Compilation manual for Clinical Symposium On Viral Diseases Demonstrating The Anti-Viral Biotic Properties Of The Drug Reticulose, 01 Sep. 1960, Miami, Florida.
"For The Viral Infection", informational compilation by Advanced Viral Research Corp., publication date not included.

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