Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-03-24
1995-05-23
Naff, David M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424435, 433215, 4332171, 435 1, 4352402, 514900, 623 16, 623 18, A61K 3700, A61K 600, A61F 1300, C12N 500
Patent
active
054182212
ABSTRACT:
Binding between parts of living mineralized tissue such as between a tooth and the jaw bone is induced with a composition containing mammalian enamel matrix isolated from tooth germs and a carrier such as water, and optionally an adhesive containing fibrinogen, factor XIII and thrombin. The enamel matrix is a precursor to tooth enamel and induces binding by forming cementum tissue. The enamel matrix may be obtained from bovine or porcine species. The composition is particularly applicable in dental therapies including loosening of teeth due to periodontitis, transplantation of teeth or in reintroduction of teeth disconnected by accident. The composition may also be used for healing of artificial implants such as tooth implants and implants of skeletal replacements such as artificial hip joints. In the case of a dislocated tooth, the composition is applied to a surface of the tooth root and the tooth is put back into its alveolus and lightly fixed for some weeks. In the treatment of periodontitis, a tooth root surface is exposed by incision, the surface is cleaned, the composition is applied to the cleaned root surface and the incision is closed and optionally stitched to promote healing.
REFERENCES:
patent: 4702734 (1987-10-01), Terranova
patent: 4728331 (1988-03-01), Russier
Copenhauer et al. Bailey's Textbook of Histology. Williams and Wilkens Co. Baltimore. p. 467, 1978.
Junqueira et al, Basic Histology, "The Teeth and Associated Structures", pp. 284-288, 1977.
Blomlof Leif
Hammarstrom Lars
Lindskog Sven
Bioventures N.V.
Naff David M.
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