Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined...
Patent
1998-06-04
2000-02-15
Naff, David M.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
424 933, 424 937, 4241951, 424538, 435410, A01N 6300, A01N 6500, A61K 3512, A61K 3564, C12N 500
Patent
active
060249846
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a composition directed to relieving physical and mental fatigue and also to ameliorating or restoring a weakened constitution, etc., which comprises muirapuama and plant worms.
2. Description of the Related Art
Muirapuama is a natural drug used in the Amazon river basin in the old days as an invigorating or restoring tonic. Plant worms are also a natural drug used in China in the old days as a sedative or an antitussive.
Orally administering compositions containing a muirapuama extract or an extract of plant worms alone as an effective ingredient are known, but a composition containing both muirapuama and plant worms together is not yet disclosed.
Dialog Information Service, File 377, Derwent Drug File, Dialog Accession No. 00510368, Derwent Accession No. 92-51335 describes the use of a composition comprising muirapuama for the treatment of physical and mental fatigue.
An object of the present invention is to provide a composition having the intensified restoring effect of muirapuamna on depressed physical strength or stamina due to stress by combining with plant worms; having the effect of relieving stress and physical fatigue; and having the effect of ameliorating or restoring a weakened constitution without any side effects, even if administered for a long time.
SUMMARY OF THE INVENTION
As a result of extensive studies, the present inventors have found a novel combination of muirapuama with plant worms, which has a synergistic effect on relieving physical and mental fatigue due to stress, and ameliorating a weakened constitution, where muirapuama can effectively normalize stress, that is, disturbances in bodies due to various external and internal factors and plant worms can effectively promote metabolism and relieve physical and mental fatigue such as a general feeling of weariness, drowsiness, and a feeling of expansion.
According to the present invention, there is provided a composition comprising muirapuama and plant worms as effect ingredients for relieving physical and mental fatigue, stress, and ameliorating a weakened constitution or recovery therefrom, without any side effects, even if administered for a long time.
Original plants for muirapuama for use in the present invention are shrubs of family Olacaceae growing in the Amazon river basin in Brazil, including such species as Ptychopetalum olacoides, Ptychopetlum uncinatum, and Liriosma ovata, among which, the species Ptychopetalum olacoides is preferable. Needless to say, the species Ptychopetlum uncinatum and Liriosma ovata can also be used. In the present invention, roots of these original plants are used.
Plant worms are stomas of preferably the genus Cordyceps of family Clavicipitaceae and larvas of insects on which the genus Cordyceps are parasitic. Those of genuses Simizuomyces, Podonectrioides, and Torrbiella of the same family Clavicipitaceae can be also used.
The muirapuama of the present invention can be used as an extract and the extract can be obtained in the following manner:
Finely shredded muirapuama roots are mixed with dilute ethanol and subjected to infusion for 2 days with occasional stirring, and the resulting infusion is filtered. The residues are further mixed with dilute ethanol and subjected to infusion for 2 days with occasional stirring and the resulting infusion is also filtered. The resulting two filtrates are combined together and concentrated under reduced pressure to obtain a muirapuama extract.
The plant worms of the present invention can be used as an extract or a fluid extract and the extracts can be obtained in the following manner:
Rough-shredded plant worms are mixed with dilute ethanol and left standing at room temperature for about 2 hours, and then the resulting solution is further mixed with dilute ethanol and subjected to infusion by leaving the solution standing at room temperature for 3 days to obtain an extract as an infusion. The thus obtained extract is left standing at room temperature for 2 days and filt
REFERENCES:
patent: 5702691 (1997-12-01), Ichinose et al.
Dialog Information Services, File 377, Derwent Drug File, Dialog Accession No. 00510368, Derwent accession No. 92-51335, Tadano T et al: "Pharmacological Studies of Nutritive and Tonic Crude Drugs on Fatigue in Mice. (Jap.)"; & Folia Pharmacol. Jpn. 100, No. 5, 423-31, 1992.
International Search Report.
Wu, "Tonic wine cont. bio. pro. of ant & silk moth" CN Abstr. 1996.
JP Abstr. Taisho Phaim Co. Ltd. "Hypersensit. drug useful . . . " JP Pat. 8048639/JP-94-79847, 1994.
Wu, "Oral liquid cont. biol. prod. of snail & turtle" CN 1126616, 95-101110, 1995. Abst. only.
Hanawa Masaaki
Kitajima Hideaki
Tsunoda Kenji
Naff David M.
Taisho Pharmaceutical Co. Ltd.
Ware Deborah K.
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