Surgery – Radioactive substance applied to body for therapy – Radioactive substance placed within body
Patent
1997-01-10
1999-02-23
Lacyk, John P.
Surgery
Radioactive substance applied to body for therapy
Radioactive substance placed within body
A61M 2902, A61N 510
Patent
active
058738118
ABSTRACT:
A method and composition for inhibiting restenosis. The composition includes an adhesive or polymeric material having a radioactive component dispersed therethrough. A biologically compatible adhesive including a radioactive material is applied to a vessel region where inhibition of restenosis is desired in a preferred method. In one composition, the radioactive material is admixed with the adhesive. In another composition, the radioactive material is chemically bonded to a polymeric adhesive. The adhesive is preferably cured in place. The radioactive material has a preferred half life of less than six months. In one method, the application of adhesive is followed by stent placement, leaving radioactive adhesive extending beyond both stent ends. The application can include forcing adhesive from a double walled balloon having a porous outer wall.
REFERENCES:
patent: 1645599 (1927-10-01), Jones
patent: 4799479 (1989-01-01), Spears
patent: 4889707 (1989-12-01), Day et al.
patent: 5030194 (1991-07-01), Van't Hooft
patent: 5059166 (1991-10-01), Fischell et al.
patent: 5084001 (1992-01-01), Van't Hooft et al.
patent: 5092834 (1992-03-01), Bradshaw et al.
patent: 5147282 (1992-09-01), Kan
patent: 5176617 (1993-01-01), Fischell et al.
patent: 5199939 (1993-04-01), Dake et al.
patent: 5213561 (1993-05-01), Weinstein et al.
patent: 5213580 (1993-05-01), Slepian et al.
patent: 5302168 (1994-04-01), Hess
patent: 5308356 (1994-05-01), Blackshear, Jr. et al.
patent: 5328471 (1994-07-01), Slepian
patent: 5354257 (1994-10-01), Roubin et al.
patent: 5411466 (1995-05-01), Hess
patent: 5417653 (1995-05-01), Sahota et al.
patent: 5421826 (1995-06-01), Crocker et al.
patent: 5484384 (1996-01-01), Fearnot
patent: 5498227 (1996-03-01), Mawad
patent: 5503613 (1996-04-01), Weinberger
patent: 5540659 (1996-07-01), Teirstein
patent: 5545132 (1996-08-01), Fagan et al.
patent: 5556389 (1996-09-01), Liprie
patent: 5558642 (1996-09-01), Schweich, Jr. et al.
patent: 5575815 (1996-11-01), Slepian et al.
patent: 5605530 (1997-02-01), Fischell et al.
patent: 5616114 (1997-04-01), Thornton et al.
patent: 5618266 (1997-04-01), Liprie
patent: 5634946 (1997-06-01), Slepian
patent: 5643171 (1997-07-01), Bradshaw et al.
patent: 5653683 (1997-08-01), D'Andrea
patent: 5662580 (1997-09-01), Bradshaw et al.
patent: 5662609 (1997-09-01), Slepian
patent: 5674177 (1997-10-01), Hehrlein et al.
patent: 5674287 (1997-10-01), Slepian et al.
patent: 5683345 (1997-11-01), Waksman et al.
Raloff, "Nuclear Medicine Gets Friendlier--Experimental Therapies Seek to Poison Just the Disease", Science News, vol. 152, Jul. 19, 1997, pp. 40-41.
Fackelmann, "Harbinger of a Heart Attack--Does a Protein in the Blood Foretell Heart Trouble", Science News, vol. 151, Jun. 14, 1997, pp. 374-375.
"Aids and Cancer Cured by Hyper-oxygenation", Now What, Issue No. 1, 1987, Waves Forest, Monterey, California.
Li et al., "Reactive Oxygen Species Induce Apoptosis of Vascular Smooth Muscle Cell", FEBS Letters, 404, 1997, pp. 249-252.
Kalli, "Oxygen Emulsion The Question of Free Radicals", Internet Address http://www.livelinks.com/sumeria/oxy/rad2.html, Aug. 1, 1997.
Barry, "Reactive oxygen Species in Living Systems--Source: Biochemistry, and Role in Human Disease", Internet Address http://www.livelinks.com/sumeria/oxy/reactive.html, Jul. 21, 1997 from American Journal of Medicine, vol. 91, No. 3C, Sep. 30, 1991, p. 14S(9).
Block, "Peroxygen Compounds, Chapter 9", Disinfection, Sterilization, and Preservation, Fourth Edition, Lea & Febiger, Philadelphia, Copyright 1991.
Moore, "Free Radial Generation by Thyroid Peroxidase and Its Effects on Cells in Vitro", PhD. Dissertation, Group in Endocrinology--University of California, Berkeley, California, Dec. 1990.
Tjho-Heslinga et al., "Results of ruthenium irradiation of uveal melanoma", Radiotherapy Oncology, Fol. 29, pp. 33-38, 1993.
Lommatzsch et al., "Radiation effects on the optic nerve observed after brachytherapy of choroidal melanomas with 106Ru/106Rh plaques", Graefe's Arch. Clin. Exp. Ophthalmology, vol. 232, pp. 482-487, 1994.
Nakayama et al., "Comparison of the Cytotyoxicity of Different Hydroperoxides to V79 Cells", Free Rad. Res. Comms., vol. 14, No. 3, pp. 173-178.
Varma et al., "Hydrogen Peroxide in Human Blood", Free Rad. Res. Comms, vol. 14, No. 2, pp. 125-131.
Sutherland, "Managing Cancer Through Synergy", Aministrative Radiology Journal, Nov. 1996, pp. 21-27.
Radiotherapty of Intraocular and Orbital Tumors, Springer-Verlak publishers, Berlin Heidelberg and New York, copyright 1993, pp. 23-30 and 363-367.
Turiumi et al., "Histotoxicity of Cyanoacrylate Tissue Adhesives", Arch Otolaryngol Head Neck Surg, vol. 116, May 1990, pp. 546-550.
Otani et al., "A new biological glue from gelatin and poly(L-glutamic acid)", Journal of Biomedical Materials Research, vol. 31, pp. 157-166 (1996).
Guilmet et al., "Use of biological glue in acute aortic dissection", Journal of Thoracic and Cardiovascular Surgery, vol. 77, No. 4, Apr. 1979, pp. 516-521.
Matras, "Fibrin Seal: The State of the Art", Max. Surg., pp. 605-611 (1985).
Kalmar et al., "Bioadhesives in Cardiac and Vascular Surgery", Thorac. Cardiovasc. Surgeon, vol. 30, 1982, pp. 230-233.
Ronis et al., "Review of Cyanoacrylate Tissue Glues with Emphasis on Their Otorhinolaryngological Applications", Laryngoscope, vol. 94, Feb. 1984, pp. 210-213.
Hastings Roger N.
Wang Lixiao
Gilbert Samuel
Lacyk John P.
Sci-Med Life Systems
LandOfFree
Composition containing a radioactive component for treatment of does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition containing a radioactive component for treatment of , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition containing a radioactive component for treatment of will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-301636