Composition comprising three platelet lesion inhibitors for plat

Details Composition comprising three platelet lesion inhibitors for plat Composition comprising three platelet lesion inhibitors for plat

1997-05-08

1999-07-06

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

424 9372, A01N 102

Patent

active

059196149

ABSTRACT:
This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to maintain their discoid shape and retain their functional integrity during storage. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets. In particular, compositions comprising amiloride, adenosine and sodium nitroprusside are disclosed.

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