Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from leguminosae
Reexamination Certificate
2005-12-27
2005-12-27
Coe, Susan D. (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from leguminosae
C514S254080
Reexamination Certificate
active
06979471
ABSTRACT:
The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside ‘glycyrrhizin’ as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.
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The Merck Index Budavari et al. (eds) (1989), 11th edition, Merck & CO., Inc: New Jersey, entry Nos. 2315, 6273, and 6617.
Registry entry for RN 1405-86-3, 2004.
Takino et al. Planta Medica (1979), vol. 36, No. 1, pp. 74-78.
Arya Jai Shankar
Awasthi Soumya
Darokar Mahendra Pandurang
Gupta Subhas Chandra
Khanuja Suman Preet Singh
Coe Susan D.
Council of Scientific and Industrial Research
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