Composition comprising pharmaceutical/nutraceutical agent...

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from leguminosae

Reexamination Certificate

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C514S254080

Reexamination Certificate

active

06979471

ABSTRACT:
The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside ‘glycyrrhizin’ as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.

REFERENCES:
patent: 5478829 (1995-12-01), Conrath
patent: 5770217 (1998-06-01), Kutilek, III et al.
patent: 5939050 (1999-08-01), Iyer et al.
The Merck Index Budavari et al. (eds) (1989), 11th edition, Merck & CO., Inc: New Jersey, entry Nos. 2315, 6273, and 6617.
Registry entry for RN 1405-86-3, 2004.
Takino et al. Planta Medica (1979), vol. 36, No. 1, pp. 74-78.

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