Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from panax or acanthopanax
Reexamination Certificate
1999-08-25
2001-08-28
Lilling, Herbert J. (Department: 1651)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from panax or acanthopanax
C424S757000, C424S773000
Reexamination Certificate
active
06280776
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to compositions comprising “
Panax pseudo-ginseng
” and “
Eucommiae ulmoides (Eucommia Bark)
”, and, if desired, comprising gallic acid-containing herbal extracts and “Licorice Root” additionally and provides a method for its production.
The composition of the present invention can be used effectively not only for human healthcare and improvement of nutritional state and immune system, but also for therapeutics or protection against hepatitis and infectious diseases, as conventional or alternative medicine and food supplements.
In addition, the composition of the present invention can be used as food supplements not only for protection against hypertension and diabetes mellitus of animals such as dogs, cats, pigs, cattle, horses and others, but also for healthcare and improvement of the nutritional state and immune system of these animals including birds and fish.
2. Description of the Related Art
Results of a nationwide survey indicate a marked increase in the number of individuals, who suffered from overweight, hypertension and diabetes mellitus, because of their environmental conditions, lack of exercise and high-calorie diets. Accordingly, ability for protection against hepatitis, infectious disease and immune disease will be markedly lowered.
These observations can be seen in the animal's environment. In fact, pet animals kept in a small area, e.g., in the rooms of a house, tend to suffer from disorders of nutritional state, hypertension, psychosomatic stress and overweight bodies with high fat mass.
On the other hand, increase of a patient's suffering with HBV and HCV are also serious problems to be solved.
In general, interferons have been used for therapy of patients suffering with HBV and HCV, although interferons had been known to have strong unfavorable side effects.
SUMMARY OF THE INVENTION
It is an object of this invention to provide food supplements and alternative medicines having an effect for significant improvements in symptoms such as high cholesterol, hypertension, diabetes mellitus and some cancers (in order to keep in healthy condition).
A further object is to provide alternative medicines which afford significant improvements in the symptoms of HBV and HCV, when compared with therapy with interferons.
The first objects of this invention have been attained by providing food supplements and the related products and alternative medicines comprising “Panax pseudo-ginseng” and “Eucommiae ulmoides”, and if desired, comprising gallic acid-containing herbal extracts and “Licorice root (Glycyrrhiza glabra)”.
Still another object of this invention is to provide alternative medicine comprising “Panax pseudo-ginseng”, “Eucommiae ulmoides”, and if desired, comprising gallic acid-containing herbal extracts and “Licorice Root”, which are effective for therapy in symptoms with various liver disorders.
Also provided herein are compositions comprising “
Panax pseudo-ginseng”, “Eucommiae ulmoides
”, gallic acid-containing herbal extracts and Licorice root (
Glycyrrhiza glabra
), which are useful as food supplements for healthcare, alternative medicine for therapy of liver disorders, supplemental products, products for drink, animal foods and food compounds for animals, birds and fish.
The present invention provides a method for production of the above-mentioned composition which comprises obtaining condensed extracts of “
Panax pseudo-ginseng
” and “
Eucommiae ulmoides
” by condensing hot-water extracts of minced dry “
Panax pseudo-ginseng
” and “
Eucommiae ulmoides
”, and if desired, their pulverized product by heat drying; obtaining condensed extracts of gallic acid-containing herbal extracts by condensing hot-water extracts of minced dry gallic acid-containing herbal extracts and if desired their pulverized products by heat drying; and mixing and then drying extracts or pulverized products of “
Panax pseudo-ginseng
” and “
Eucommiae ulmoides
”, extracts or pulverized products of gallic acid-containing herbal extracts, and extracts or pulverized products of “Licorice Root”.
Alternative medicines, food supplements, products for drinking and healthcare food for humans and animals comprising the above compositions are effective for lowering blood, sugar and cholesterol and for enhancing the immune system.
In addition, the composition of the present invention shows the effect of lowering the elevated GOT and GTP levels. Especially, oral administration of compositions containing gallic acid-containing herbal extracts resulted in the reduction of elevated a-Fetoprotein and albumin in humans, suggesting that compositions of the present invention may be effective for prevention or reduction of the symptoms connected with high blood cholesterol, hypertension and diabetes mellitus, and also useful for prevention of chronic hepatitis. Although gallic acid-containing herbal extracts themselves have been known to be difficult to absorb into human or animal bodies, compositions of this invention comprising gallic acid-containing herbal extracts can be readily absorbed into human and animal bodies.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
This invention utilizes the root of
Panax pseudo
-
ginseng
(Wall). This Chinese herb has been known to improve lipid metabolic failure, and to control hypertension and pain relief.
Eucommia bark generally consists of dried bark of Eucommiae ulmoides. This Chinese herb has been known to reduce hypertension and high blood lipid level.
The Eucommiae ulmoides in this invention, however, not only refers to “Eucommia bark” but also includes leaves and fruits of Eucommiae ulmoides.
“Denhichi-Tochu-Sei” is a novel composition of Chinese herbs comprising Panax pseudo-ginseng and Eucommia bark, which was invented by the present inventors. “Denhichi-Tochusei” is produced by extracting the root of Panax pseudo-ginseng and the Eucommiae ulmoides with hot water. The composition “Denhichi-Tochu-Sei” can contain honey and Panax ginseng (Chinese Ginseng) as additives.
The word “Denhichi-Tochu-Sei” of the present invention indicates the composition comprising dried extracts of Chinese herbs, such as Panax Pseudo Ginseng and Eucommia mainly.
In “Denhichi-Tochu-Sei” of the present invention the compositions of Chinese herbs are
Panax pseudo-ginseng
(Denhichi) 10~90 weight %, Eucommiae ulmoides (Tochu) 10~90 weight %, Panax ginseng (Chinese Ginseng), 0~20 weight %, preferably 5~20 weight %, and honey 0~30 weight %. A preferable composition for Denhichi-Tochu-Sei of the present invention is 30 weight % of Panax pseudo-ginseng, 40 weight % of Eucommiae ulmoides, 20 weight % of Panax ginseng (Chinese Ginseng) and 10 weight % of honey, or 30 weight % of Panax pseudo-ginseng, 40 weight % of Eucommiae ulmoides, 10 weight % of Panax ginseng (Chinese Ginseng), 10 weight % of honey and 10 weight % of others.
In this invention, although the most preferable ratio of Panax pseudo ginseng and Eucommiae ulmoides in the composition is 3:4, even at the 1:0.1~1:9 ratio, biological effects such as lowering blood pressure and blood cholesterol and enhancing immune condition are still retained.
Gallic acid is 3,4,5-trihydroxybenzoic acid, which is contained in “Gallae halepensis”, “Gallae rhois”, “Gallae chinensis” as well as other herbs, which are used as Chinese medicines. The gallic acid-containing herbal extracts include these Chinese medicines.
Licorice root was obtained from the roots or kernels of Glycyrrhiza glabra Linn.
Glycyrricine, which is a main component of Licorice root, has been known to improve several symptoms with liver injuries and to elevate the serum transaminase by the double blind examination.
Further, glycyrricine has been shown to protect CCI
4
-induced liver injury (Matsushima, Rinsho & Kenkyu, vol. 56(10), 345-(3461)(1979)).
Composition (Denhichi-Tochu-Sei) and compositions containing Denhichi-Tochu-Sei, extracts of Gallae rhois and Licorice root in the present invention, dissolve in water and are readily absorbed into the living body, and were found to afford the ef
Sha Shinhan
Yanaihara Noboru
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Lilling Herbert J.
Sha Shinhan
LandOfFree
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