Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 3,10-dihydroxy-2-naphthacene carboxamide or derivative doai
Patent
1992-09-04
1994-05-03
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
3,10-dihydroxy-2-naphthacene carboxamide or derivative doai
514414, 514418, 514419, A61K 3165, A61K 3140
Patent
active
053088395
ABSTRACT:
A method for treating mammals suffering from rheumatoid arthritis, other tissue-destructive conditions, and chronic inflammatory or other conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, but that is not effectively antimicrobial, and an amount of a non-steroidal anti-inflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss.
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Golub Lorne M.
Greenwald Robert A.
McNamara Thomas F.
Ramamurthy Nangavarum S.
Criares T. J.
The Research Foundation of State University of New York
Waddell Frederick E.
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