Composition comprising methylphenidate and another drug

Details Composition comprising methylphenidate and another drug Composition comprising methylphenidate and another drug

1996-07-15

1998-06-30

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514438, 514810, 514813, 514922, 424490, 424 91, 424 92, 435 4, 435 74, 435 771, 435 791, A01N 3302, A01N 4306, A61K 31135, A61K 916

Patent

active

057734780

ABSTRACT:
A method of treating a subject that is undergoing methylphenidate therapy and concomitant therapy with another drug undergoes or interferes with P.sub.450 metabolism, wherein the methylphenidate is d-threo-methylphenidate.

REFERENCES:
Patrick, K. S. et al. (1987) "Pharmacology of the Enantiomers of threo-Methylphenidate" The Journal of Pharmacology and Experimental Therapeutics 241(1):152-158.
Eckerman, D.A. et al. (1991) "Enantioselective Behavioral Effects of threo-Methylphenidate in Rats" Pharmacology Biochemistry & Behavior 40(4):875-880.
Aoyama, T. et al. (1994) "Pharmacokinetics and pharmacodynamics of (+)-threo-methylphenidate enantiomer in patients with hypersomnia" Clinical Pharmacology & Therapeutics 55(3):270-276.
Ariens, E.J. (1991) "Racemic therapeutics--ethical and regulatory aspects" Eur J Clin Pharmacol 41:89-93.
Ariens, E.J. (1990) "Stereoselectivity in pharmacodynamics and pharmacokinetics" Schweiz. Med. Wochenschr. 120(5):131-134.
Tyndale, R.F. et al. (1991) "Neuronal Cytochrome P450IID1 (Debrisoquine/Sparteine-Type): Potent Inhibition of Activity (--)-Cocaine and Nucleotide Sequence Identity to Human Hepatic P450 Gene CYPsD6" Molecular Pharmacology, An International Journal 40(1):63-68.
Rapport, M.D. et al. (1993) "Methylphenidate and desipramine in hospitalized children: I. Separate and combined effects on cognitive function" J. Am. Acad. Child Adolesc. Psychiatry 32(2):333-342, **abstract only.
Licamele, W.L. et al. (1989) "The concurrent use of lithium and methylphenidate in a child" J. Am. Acad. Child Adolesc. Psychiatry 28(5):785-787, **abstract only.
Grob, C.S. et al. (1986) "Suspected adverse methylphenidate-imipramine interactions in children" J. Dev. Behav. Pediatr. 7(4):265-267, **abstract only.
Drimmer, E.J. et al. (1983) "Desipramine and methylphenidate combination treatment for depression: case report" Am. J. Psychiatry 140(2):241-242, **abstract only.

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