Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Cancer cell or component thereof
Reexamination Certificate
2005-01-04
2005-01-04
Nickol, G. (Department: 1642)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Cancer cell or component thereof
C424S093100, C435S002000, C435S440000, C435S455000
Reexamination Certificate
active
06838086
ABSTRACT:
The invention discloses the use of low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, for producing vaccines. The vaccines are particularly suitable for controlling cancer diseases. Surprisingly, it has been found that low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, can be used both for preparing mature dendritic cells and directly, together with antigens or peptides or carrier systems, as an adjuvant in vaccines. It is likewise possible to couple the low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, to an antigen, peptide or carrier system. The coupled system can then be advantageously employed as a vaccine, in particular for treating cancer diseases.
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Termeer, C. et al., “Dendritic Cell (DC) Maturation by Small Fragments of Hyaluronan (HA) Involves a Highly Specific Nf-01ℏB and TNF01α-Dependent Pathway”, Journal of Investigative Dermatology, Abstracts for the 60th Annual Meeting of the Society for Investigative Dermatology, May 5-9, 1999, pp. 579, vol. 12, No. 4.
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Martin Stefan
Simon Jan
Termeer Christian
Heller Ehrman White and McAuliffe LLP
Nickol G.
Universitaetsklinikum Freiburg
Yaen C
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