Composition comprising low molecular weight hyaluronic acid...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Cancer cell or component thereof

Reexamination Certificate

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C424S093100, C435S002000, C435S440000, C435S455000

Reexamination Certificate

active

06838086

ABSTRACT:
The invention discloses the use of low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, for producing vaccines. The vaccines are particularly suitable for controlling cancer diseases. Surprisingly, it has been found that low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, can be used both for preparing mature dendritic cells and directly, together with antigens or peptides or carrier systems, as an adjuvant in vaccines. It is likewise possible to couple the low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, to an antigen, peptide or carrier system. The coupled system can then be advantageously employed as a vaccine, in particular for treating cancer diseases.

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Termeer, C. et al., “Dendritic Cell (DC) Maturation by Small Fragments of Hyaluronan (HA) Involves a Highly Specific Nf-01ℏB and TNF01α-Dependent Pathway”, Journal of Investigative Dermatology, Abstracts for the 60th Annual Meeting of the Society for Investigative Dermatology, May 5-9, 1999, pp. 579, vol. 12, No. 4.
Nobel, P. W. et al., “Induction of inflammatory gene expression by low-molecular-weight hyaluronan fragments in macrophages”, Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives, 1998, pp. 219-225, vol. 72, Wenner-Gren Int. Ser.

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