Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from a stem – stalk – branch – or twig
Reexamination Certificate
2009-05-14
2010-12-07
Tate, Christopher R. (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from a stem, stalk, branch, or twig,
C424S777000
Reexamination Certificate
active
07846484
ABSTRACT:
The present invention relates to a method for treating or preventing fibrosis and improving kidney function comprising administering aHovenia dulcisThunb extract and/or aLindera obtusilobaextract to the subject. The method of the present invention can lower the level of GOT, GPT, ALP, BUN and total bilirubin; improve kidney functions; lower the amount of hydroxyproline in liver but increase the amount of hydroxyproline in kidney, suggesting that the extract above has excellent anti-fibrosis and kidney protecting effects; lower the level of malondialdehyde, suggesting that the extract has excellent anti-oxidative effect; and promote cell viability in liver and kidney cell lines, indicating that the extract has excellent liver and kidney cell protective effects.
REFERENCES:
patent: 5879709 (1999-03-01), Soon-Shiong et al.
patent: 2004/0058016 (2004-03-01), Na et al.
patent: 2003128571 (2003-05-01), None
patent: 100214801 (1999-05-01), None
patent: 100076980 (2002-10-01), None
patent: 100403722 (2003-10-01), None
patent: 100543082 (2006-01-01), None
patent: WO 02/060463 (2002-08-01), None
patent: WO 03/059369 (2003-07-01), None
Cho, J-Y et al., “Isolation and Identification of 3-Methoxy-4-hydroxybenzoic Acid and 3-Methoxy-4-hydroxycinnamic Acid from Hot Water Extracts ofHovenia dulcisThunb and Confirmation of Their Antioxidative and Antimicrobial Activity,” Korean J. Food Sci. Technol. 32(6):1403-1408, 2000, Abstract only.
Hase, K. et al., “Hepatoprotective effect ofHovenia dulcisTHUNB. on experimental liver injuries induced by the carbon tetrachloride or D-galactosamine/lipopolysaccharide,” Biol. Pharm. Bull. Apr. 20(4):381-385, 1997, Abstract only.
Yoshikawa, M. et al., “Bioactive constitutents of Chinese natural medicines. III. Absolute stereostructures of new dihydroflavonols, hovenitins I, II, and III, isolated from hoveniae semen seu fructus, the seed and fruit ofHovenia dulcisThunb. (Rhamnaceae); inhibitory effect on alcohol-induced muscular relaxation and hepatroprotective activitry,” Yakugaku Zasshi Feb. 117(2):108-118, 1997, Abstract only.
Kim Ki-young
Kim Kwangsang
Davis Deborah A.
Greenlee Sullivan P.C.
Jangheunggun Mushroom Research Institute
Kim Kiyoung
Tate Christopher R.
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