Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 3,10-dihydroxy-2-naphthacene carboxamide or derivative doai
Patent
1991-08-12
1994-06-14
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
3,10-dihydroxy-2-naphthacene carboxamide or derivative doai
514570, 514557, 514420, 514825, A61K 3165, A61K 3119, A61K 3140
Patent
active
053210174
ABSTRACT:
A method for treating mammals suffering from rheumatoid arthritis and other tissue-destructive (chronic inflammatory or other) conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, but that is not effectively antimicrobial, and an amount of non-steroidal anti-inflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss.
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Golub Lorne M.
Greenwald Robert A.
McNamara Thomas F.
Ramamurthy Nangavarum S.
Criares T. J.
The Research Foundation of State University of New York
Waddell Frederick E.
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