Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-06-07
2000-02-01
Mertz, Prema
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
424 111, 424 149, 5303879, 5303881, 53038822, 53038823, 53038885, 5303892, 5303913, 5303917, A61K 39395
Patent
active
060199695
ABSTRACT:
An inflammatory cytokine is disclosed which has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine comprises a protein that is capable of binding to heparin, inducing localized inflammation characterized by polymorphonuclear cell infiltration when administered subcutaneously and inducing in vitro polymorphonuclear cell chemokinesis, while lacking the ability to suppress the activity of the anabolic enzyme lipoprotein lipase, cause the cytotoxicity of cachectin/TNF-sensitive cells, stimulate the blastogenesis of endotoxin-resistant C3H/HeJ thymocytes, or induce the production of cachectin/TNF by primary thioglycollate-elicited mouse macrophage cells. A particular inflammatory cytokine MIP-1 has been isolated and has been found to comprise a peptide doublet of similar molecular weights of about 8,000 daltons, and to show a pI of about 4.6. The doublet has been resolved into its component peptides, MIP-1.alpha. and MIP-1.beta. for which distinct cDNA's have been cloned and sequenced. Diagnostic and therapeutic utilities are proposed, and testing procedures, materials in kit form and pharmaceutical compositions are likewise set forth.
REFERENCES:
patent: 4603106 (1986-07-01), Cerami et al.
patent: 5145676 (1992-09-01), Fahey, III et al.
Sherry et al. (1992) Cytokines 4: 117-30.
Sherry et al. (1991) Curr. Opin. Immunol. 3: 56-60.
Dinarello et al. (1977) Proc. Natl. Acad. Sci. USA 74: 4624-7.
Voller et al. (1976) Bull. World Health Organ. 53: 55-65.
Brown et al. (1972) Bioch. Biophys. Res. Commun: 375-82.
Brown et al. (1989) J. Immunol. 142: 679-87.
Sporn et al. (1989) J. Immunol. 144: 4434-4441.
Wolpe et al. (1989) FASEB J. 3: 2565-73.
Yoshimura et al. (1989) FEBS Letts. 224:487-93.
Zipfel et al. (1989) J. Immunol. 142: 1582-90.
Davatelis et al. (1988) J. Exp. Med. 167:1939-44.
Lipes et al. (1988) Proc. Natl. Acad. Sci. USA 85: 9704-8.
Matsushima et al. (1988) J. Exp. Med. 167: 1883-93.
Sherry et al. (1988) J. Exp. Med. 168: 2251-9.
Wolpe et al. (1988) J. Exp. Med. 167: 570-81.
Sassa et al. (1987) Blood Cells 13: 161-9.
Wolpe et al. (1987) in The inhibitors of hamatopoiesis, Najman et al. eds. pp. 197-200.
Yoshimura et al. (1987) J. Immunol. 139: 788-93.
Yoshimura et al. (1987) Proc. Natl. Acad. Sci. USA 84: 9233-7.
Caput et al. (1986) Proc. Natl. Acad. Sci. USA 83: 1670-4.
Reeves et al. (1986) Proc. Natl. Acad. Sci. USA 83: 3228-32.
Kownatzki et al. (1986) Clin. Exp. Immunol. 64: 214-22.
Obaru et al. (1986) J. Biochem. 99: 885-94.
Beutler et al. (1985) Nature 316: 552-4.
Beutler et al. (1985) Science 229: 869-71.
Mahoney et al. (1985) J. Immunol. 134: 1673-1675.
Torti et al. (1985) Science 229: 867-9.
W.E. Paul, ed. (1984) Fundamental Immunology. p. 706.
Hotez et al. (1984) Parasite Immunol. 6:203.
Lomdedico et al. (1984) Nature 312: 458-62.
Kawakami et al. (1982) Proc. Natl. Acad. sci. USA: 79: 912-16.
Kawakami et al. (1981) J. Exp. Med. 154: 631-9.
Merrill et al. (1980) J. Clin. Invest. 65: 268-76.
Kampschmidt et al. (1980) J. Lab. Clin. Med. 95: 616-23.
Tono-Oka et al. (1980) Immnunol. 39: 607-13.
Sipe et al. (1979) J. Exp. Med. 150: 597-606.
Obanu et al. (1986) J. Biochem. vol. 99, p. 885-894.
Lerner (1982) Nature vol. 299, pp. 592-596.
Beutler Bruce
Cerami Anthony
Wolpe Stephen D.
Mertz Prema
The Rockefeller University
LandOfFree
Composition comprising antibody to macrophage-derived inflammato does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition comprising antibody to macrophage-derived inflammato, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition comprising antibody to macrophage-derived inflammato will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-935153