Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1986-01-27
1988-05-10
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514863, A61K 3156
Patent
active
047435976
ABSTRACT:
The invention is directed to a pharmaceutical composition comprising an oxygenated cholesterol and a penetration-enhancing agent which is useful for topical application to the skin of a patient suffering from a proliferative skin disease characterized by geminative cells having a rapid rate of replication, e.g. psoriasis. The composition comprises an effective amount for the inhibition of germinative cell mitosis of an oxygenated cholesterol, e.g. 26-hydroxycholesterol, or a pharmaceutically effective derivative thereof e.g. an ester or ether. The invention is further directed to a method of treating a patient suffering from said skin disease comprising applying to the effected skin said therapeutic composition. The invention is also directed to the topical application of these compositions to the skin to decrease inflammation.
REFERENCES:
patent: 3551554 (1970-12-01), Herschler
patent: 4316893 (1982-02-01), Rajadhyaksha
patent: 4427668 (1984-01-01), Javitt
patent: 4432976 (1984-02-01), Annen et al.
Javitt Norman B.
Stoughton Richard B.
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