Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-06-07
2000-08-15
Mertz, Prema
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
514 2, 514 8, 514 12, 514885, 530351, A61K 39395
Patent
active
061032344
ABSTRACT:
An inflammatory cytokine is disclosed which has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine comprises a protein that is capable of binding to heparin, inducing localized inflammation characterized by polymorphonuclear cell infiltration when administered subcutaneously and having potent in vitro chemotactic activity while inducing little or no in vitro chemokinesis in polymorphonuclear cells, while lacking the ability to suppress the activity of the anabolic enzyme lipoprotein lipase, cause the cytotoxicity of cachectin/TNF-sensitive cells, stimulate the blastogenesis of endotoxin-resistant C3H/HeJ thymocytes, or induce the production of cachectin/TNF by primary thioglycollate-elicited mouse macrophage cells. A particular inflammatory cytokine has been isolated and its cDNA has been sequenced. The sequence predicts a cDNA of 74 amino acids in length and a molecular weight of 7,908. Diagnostic and therapeutic utilities are proposed, and testing procedures, materials in kit form, recombinant materials and procedures, and pharmaceutical compositions are likewise set forth.
REFERENCES:
patent: 3654090 (1972-04-01), Schuurs et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 4603106 (1986-07-01), Cerami et al.
patent: 4961926 (1990-10-01), Gabrilove
patent: 5145676 (1992-09-01), Fahey, III et al.
Sherry et al. (1992) Cytokines 4: 117-30.
Sherry et al. (1991) Curr. Opin. Immunol. 3: 56-60.
Widmer et al. (1991) J. Immunol. 146: 4031-40.
Baker et al. (1990) Nucl. Acids Res. 18: 6453.
Dexter et al. (1990) Nature 344: 380-1.
Graham et al. (1990) Nature 344: 442-4.
Haskill et al. (1990) Proc. Natl. Acad. Sci. USA 87: 7732-6.
Davatelis et al. (1989) Science 243: 1066-8.
Wolpe et al. (1989) FASEB J. 3: 2565-73.
Yoshimura et al. (1989) FEBS Letts. 224:487-93.
Kampschmidt, R.F. (1978) J. Ret. Soc. 23:287-97.
Dinarello et al. (1977) Proc. Natl. Acad. Sci. USA 74: 4624-7.
Matsushima et al. (1988) J. Exp. Med. 167: 1883-93.
Peveri et al. (1988) J. Exp. Med. 167: 1547-59.
Van Damme et al. (1988) J. Exp. Med. 167: 1364-76.
Sherry et al. (1988) J. Exp. Med. 168: 2251-9.
Barney et al. (1980) Fever: International Symposium, Dallas TX, Apr. 11-12, 1979. XII + 263 P, ISBN 0-89004-451-1(08877) pp. 111-122.
Kampschmidt et al. (1980) J. Lab. Clin. Med. 95: 616-23.
Sipe et al. (1979) J. Exp. Med. 150: 597-606.
Walz et al. (1987) Bioch. Biophys. Res. Comm. 149: 755-61.
Wolpe et al. (1987) in The inhibitors of hamatopoiesis. Najman et al. eds, pp. 197-200.
Yoshimura et al. (1987) J. Immunol. 139: 788-93.
Yoshimura et al. (1987) Proc. Natl. Acad. Sci. USA 84: 9233-7.
Torti et al. (1985) Science 229: 867-9.
Beutler et al. (1985) Science 229: 869-71.
Mahoney et al. (1985) J. Immunol. 134: 1673-1675.
Beutler et al. (1985) Nature 316: 552-4.
Hotez et al. (1984) Parasite Immnuol. 6:203-9.
Cochran et al. (1983) Cell 33: 937-47.
Kawakami et al. (1982) Proc. Natl. Acad. Sci. USA: 79: 912-16.
Kahan (1992) Current Opinion in Immunology vol. 4, pp. 553-560.
Cerami Anthony
Sherry Barbara
Tekamp-Olson Patricia A.
Wolpe Stephen D.
Mertz Prema
The Rockefeller University
LandOfFree
Composition comprising an antibody to macrophage-derived inflamm does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition comprising an antibody to macrophage-derived inflamm, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition comprising an antibody to macrophage-derived inflamm will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2003725