Composition composed of an aqueous dispersion of stabilized vesi

Details Composition composed of an aqueous dispersion of stabilized vesi Composition composed of an aqueous dispersion of stabilized vesi

1996-10-28

1999-02-02

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424401, 4284022, A61K 9127, A61K 700

Patent

active

058661581

ABSTRACT:
The vesicles are prepared from a lipid phase containing a mixture of nonionic amphiphilic lipids consisting of a mixture of esters of at least one polyol chosen from the group composed of polyethylene glycol containing from 1 to 60 ethylene oxide units, sorbitan, sorbitan bearing 2 to 60 ethylene oxide units, glycerol bearing 2 to 30 ethylene oxide units, polyglycerols containing 2 to 15 glycerol units, sucroses, and glucoses bearing 2 to 30 ethylene oxide units and of at least one fatty acid containing a saturated or unsaturated, linear or branched C.sub.5 -C.sub.17 alkyl chain, the number of alkyl chains per polyol group being between 1 and 10, the mixture being stabilized with ionic amphiphilic lipid or lipids chosen from the group composed of those which impart a pH of between 5.5 and 7.5 to the dispersion.

REFERENCES:
patent: 4670185 (1987-06-01), Fujiwara
patent: 4832944 (1989-05-01), Socci
patent: 5229104 (1993-07-01), Sottery
patent: 5246693 (1993-09-01), Grollier
patent: 5290562 (1994-03-01), Meybeck
French Search Report--FR 92 09603.
French Search Report--FR 92 12343.

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