Composition and use

Details Composition and use Composition and use

1997-06-17

1999-12-21

Cain, Edward J.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Processes of preparing a desired or intentional composition...

524 83, 524 84, C08K 545

Patent

active

060050322

DESCRIPTION:

BRIEF SUMMARY
This application is the national phase of international application PCT/GB95/02951, filed Dec. 18, 1995 which was designated the U.S.
The present invention relates to the use of 2-alkyl- and 2-aralkyl-1,2-benzisothiazolin-3-ones as biocides for the protection of plastics materials and especially their use as fungicides, including compositions thereof. 1,2-benzisothiazolin-3-ones (hereinafter "BIT") and their use as biocides are well known to the art.
GB 848,130 discloses BIT's containing inter alia a 2-alkyl substituent containing at least 4 carbon atoms or a 2-benzyl group substituted by halogen. These compounds are said to possess useful anti-bacterial and antifungal activity and are of use as pharmaceutical, vetinary and agricultural biocides.
U.S. Pat. No. 3,517,022 discloses BIT's containing inter alia a 2-alkyl substituent having from 4 to 24 carbon atoms and where the phenyl ring of the BIT is substituted by halogen, C.sub.1-4 -alkyl or C.sub.1-4 -alkoxy. Such compounds are said to be useful industrial biocides, especially agricultural fungicides and also pesticides.
GB 1,531,431 discloses 2-(C.sub.1-3 -alkyl)-BIT's and their use as industrial biocides, including fungicides, in aqueous systems and paint films.
More recently, EP 475,123 has proposed the use of 2-(n-C.sub.6-8 -alkyl)-BIT's as industrial biocides and especially fungicides for paint and plastics materials. These compounds are said to be particularly effective against Scopulariopsis brevicaulis. Furthermore, the 2-(n-C.sub.6-8 -alkyl)-BIT's are stated to have much higher activity against mould fungi that the 2-(C.sub.1-3 -alkyl)-BIT's of GB 1,531,431. Indeed, data is presented which shows that the 2-n-octyl-BIT is more active than 2-n-hexyl-BIT and both are significantly more active than 2-methyl-BIT against fungi and yeast.
It has now been found that some 2-alkyl-BIT derivatives are very active against fungal deteriogens for plastics materials and contrary to the recent teachings of EP 475,123 the activity of these compounds against the important fungi in plastics materials actually decreases with increasing number of carbon atoms in the 2-alkyl chain. It has also been found that some 2-aralkyl-BIT derivatives are also very active against these particular fungi in plastics materials.
A further important property which is required by a fungicide for plastics materials is the ability to withstand the processing conditions to which the material is subjected during fabrication processes such as extrusion. This generally involves heating the plastics materials at temperatures in excess of 140.degree. C. It is therefore important that the fungicide exhibits high temperature stability and low volatility under such conditions.
It has now been found that the more active BIT-derivatives exhibit too high a volatility to make than suitable as fungicides for plastics materials and that the 2-alkyl group must contain not less than 3 carbon atoms. The 2-aralkyl-BIT derivatives exhibit acceptable and very advantageous low volatility.
A still further important requirement for a fungicide for plastics materials is that it must be capable of formulation with plasticisers and stabilisers which are commonly used in the plastics materials fabrication industry and that the fungicide exhibits high resistance to discoloration in use and longevity of effect under various conditions to which the treated plastics materials are exposed in use.
It has been found that certain 2-alkyl and 2-aralkyl BIT derivatives (hereinafter "ABIT") meet the aforementioned requirements especially in respect of volatility and activity against fungal deteriogens for plastics materials.
According to the invention there is provided the use of 2-alkyl- and 2-aralkyl-BIT derivatives of Formula 1 as fungicides for plastics materials ##STR1## wherein R.sup.1 is hydroxy, halogen, C.sub.1-4 -alkyl or C.sub.1-4 -alkoxy; carbon atoms linking the aryl group to the nitrogen atom and where the alkyl or aryl group may be optionally substituted; and
Preferably, halogen is bromine and especially chlo

REFERENCES:
patent: 5246812 (1993-09-01), von Trebra et al.

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